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AN IN VITRO ROBOTIC ASSAY FOR ESTROGENIC ACTIVITY

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43ES011469-01
Agency Tracking Number: ES011469
Amount: $90,995.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
CERTICHEM, INC. 5105 EVANS AVE, STE 101
AUSTIN, TX 78751
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 CATHY YANG
 (512) 346-1394
 CZYANG@AUSTIN.RR.COM
Business Contact
  CONTROLLER
Phone: (512) 458-3331
Email: JRMUSIL@AUSTIN.RR.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Recent scientific investigations have
shown that many chemicals used in plastics, pharmaceuticals, pesticides,
cosmetics, food additives, etc., are endocrine disruptors that interfere in
various ways with the action of estrogen, androgen, or thyroid hormones. The
most common endocrine effects of disruptor involve estrogenic activity that can
have significant deleterious effects on many physiological processes at very
low (picomolar to nanomolar) concentrations, especially on fetal or developing
mammals. The prevalence and actions of endocrine disruptors in our environment
warrants the development of highly specific, sensitive, reliable, rapid, and
cost-effective detection. A high throughput robotic cell proliferation assay
would constitute such a test. Hence, in this SBIR Phase I proposal, CertiChem
proposes to develop a high throughput robotic assay to detect estrogenic
activity by measuring in vitro proliferation of MCF-7 cells. Such a robotic
screening assay should be commercially important because of the large number of
chemicals (> 10,000) and mixtures of chemicals that should be screened for
estrogenic activity by profit, non-profit, or governmental entities. Our
preliminary data demonstrate that CertiChem has the expertise to develop this
in vitro robotic assay for estrogenic activity.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* Information listed above is at the time of submission. *

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