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Development of a Database Management System to Enable Rapid, Efficient Assay Design for Use in Detection and Diagnosis of Human Exposure to Biological

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W81XWH-07-C-0065
Agency Tracking Number: C071-114-0042
Amount: $99,909.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD07-114
Solicitation Number: 2007.1
Timeline
Solicitation Year: 2007
Award Year: 2007
Award Start Date (Proposal Award Date): 2007-05-10
Award End Date (Contract End Date): 2007-11-09
Small Business Information
215 Wynn Dr., 5th Floor, Huntsville, AL, 35805
DUNS: 185169620
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Jerry Jenkins
 Group Leader
 (256) 726-4800
 tsb@cfdrc.com
Business Contact
 Deb Phipps
Title: Contract Specialist
Phone: (256) 726-4800
Email: dap@cfdrc.com
Research Institution
N/A
Abstract
The primary objective of this effort is to design and develop a database management system (DBMS) and enable the integrated interpretation of the vast amounts of genomic and proteomic data in proper biological context. This DBMS will enable the development of diagnostic assays for human exposure to specific biological threat agents using an existing suite of systems biology tools. The DBMS design will be clearly described, and it will manage diverse data types based on the principles of minimum information about a microarray experiment (MIAME). Demonstration of the database for data storage/retrieval/querying will be performed with an example assay design using the systems biology approach to interpret biological data in context. Successful completion of the Phase I effort will generate a DBMS containing a suite of tools enabling analysis from a systems biology-centered approach, providing a rational basis for designing assays. In Phase II, the project scope will be expanded to include additional data types, a GUI, links to relevant online databases, and validation of the systems biology centered methodologies will be undertaken. A multi-disciplinary team has been assembled, and this project will benefit from multiple, ongoing efforts utilizing in-house systems biology tools to understand cellular response to neurotoxins.

* Information listed above is at the time of submission. *

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