Spatial and Temporal Control of Tissue Growth using DNA Aptamers

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$99,917.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-10-C-0160
Award Id:
96855
Agency Tracking Number:
O093-H10-3081
Solicitation Year:
n/a
Solicitation Topic Code:
OSD 09-H10
Solicitation Number:
n/a
Small Business Information
303 Bear Hill Road, Waltham, MA, 02451
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
004627316
Principal Investigator:
Vladimir Gilman
Principal Scientist
(781) 890-1338
vgilman@infoscitex.com
Business Contact:
Stephen Mattox
Director, Finance & Contracts
(781) 890-1338
smattox@infoscitex.com
Research Institution:
n/a
Abstract
The clinical need for improved craniofacial reconstruction materials drives the development of new tissue engineering scaffold materials to alleviate inherent problems with the current best practice, allo- and auto-grafting. Infoscitex, in collaboration with Tufts University and Serica Technologies, presents a novel silk fibroin derived scaffolding material, customizable to many form factors with tunable material properties, coated with cell-specific aptamers to promote selective affixation of mesenchymal stem cells, with the goal of reducing wound healing time and promoting vascularization through the depth of the scaffold. In Phase I, we will isolate aptamers that selectively bind to highly conserved identity regions of mesenchymal stem cells, affix these aptamers to the surface of Serica Technology''s SeriScaffold, and demonstrate in vitro that the treated scaffolds show an increased MSC affinity, viability, proliferation, and differentiation. In Phase II, we will transition to in vivo studies and demonstrate that with the addition of embedded chemokine signals, angiogenesis through the scaffold is enhanced and wound healing is more rapid and complete.

* information listed above is at the time of submission.

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