POLYATOMIC PRIMARY BEAM FOR SIMS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19419
Agency Tracking Number:
19419
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
301 Chesapeake Drive, Redwood City, CA, 94063
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Constance M John
(415) 369-4567
Business Contact:
() -
Research Institution:
n/a
Abstract
A PHASE II NIH SBIR GRANT FOR ION IMAGING ANALYSIS OF BIOLOGICAL MATRICES PREVIOUSLY AWARDED TO CHARLES EVANS AND ASSOCIATES, IS PRODUCING VERY PROMISING RESULTS. THIS RESEARCH USES TOF-SIMS WHICH STIGMATICALLY FOCUSES SECONDARY IONS PRODUCED BY BOMBARDMENT WITH A CS(+) PRIMARY BEAM. THIS INSTRUMENTATION CAN ALSO PRODUCE ION IMAGES USING A RASTERED MICROFOCUSSED PRIMARY ION BEAM, A LIQUID METAL ION GUN WHICH PRODUCES (69)GA(+). SIMS ANALYSIS OF VARIOUS BIOMOLECULES IN TISSUE-LIKE MODEL MATRICES USING THE MONATOMIC PRIMARY ION BEAMS IS NOT PRODUCING SUFFICIENT SECONDARY IONS FOR HIGH QUALITY ION IMAGING OF MOLECULES AT THE CONCENTRATIONS TYPICALLY ENCOUNTERED IN TISSUE. IN OTHER LABORTORIES INCREASES IN SECONDARY ION YIELD OF MORE THAN AN ORDER OF MAGNITUDE HAVE BEEN OBTAINED USING POLYATOMIC, RATHER THAN MONATOMIC, PRIMARY ION BEAMS. THE FIRST OBJECTIVE OF THIS PHASE I RESEARCH IS TO ADAPT THE TOF-SIMS MASS SPECTROMETER TO A POLYATOMIC PRIMARY IONBEAM SOURCE AND PRODUCE A BROAD BEAM OF AU CLUSTER IONS. WITH THIS PRIMARY BEAM, ION IMAGING COULD BE PERFORMED BY STIGMATICALLY FOCUSSING THE SECONDARY IONS. THE SECOND OBJECTIVE IS TO DETERMINE THE DETECTION LIMITS AND SECONDARY ION YIELDS OF SELECTED BIOMOLECULES IN THE TISSUE-LIKE MODEL MATRICES, AND, ALSO IN TISSUE SAMPLES, AND COMPARE THEM WITH THOSE OBTAINED WITH MONATOMIC PRIMARY ION BEAMS.

* information listed above is at the time of submission.

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