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Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf Activation Pathway

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AG053128-01A1
Agency Tracking Number: R43AG053128
Amount: $209,928.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIA
Solicitation Number: PA15-269
Timeline
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-04-01
Award End Date (Contract End Date): 2018-09-30
Small Business Information
12635 E MONTVIEW BLVD STE 130
Aurora, CO 80045-7336
United States
DUNS: 079599519
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BROOKS HYBERTSON
 (970) 492-4418
 brooks@symbiostechnologies.com
Business Contact
 BROOKS HYBERTSON
Phone: (720) 301-4579
Email: brooks@pathwaysbio.com
Research Institution
N/A
Abstract

The average lifespan and the number of older individuals is increasing in the US but because
age is a primary risk factor for most chronic disease there is an accompanying increase in the
burden of chronic disease in the US Diet and lifestyle choices including dietary
supplementation may be useful approaches to slowing the aging process and increasing
healthspan and also may be the best strategy for minimizing the burden of many chronic
diseases One promising approach to supporting healthy aging is protecting the body by
inducing upregulation of its own cell survival genes through dietary supplementation with
phytochemical combinations that activate the Nrf NFE L Nuclear Factor Erythroid Like
cell signaling pathway At Pathways Bioscience we are developing a dietary supplement
combination PB that synergistically activates the Nrf cell signaling pathway which in turn
upregulates antioxidant anti inflammatory and other cell protective genes and is a promising
candidate for improving health status during aging The phytochemicals in PB were
specifically selected because they act at different control points on the Nrf activation pathway
so that small amounts of each are able to work synergistically together to create relevant Nrf
activation responses and gene expression This is an innovative approach being developed by
Pathways Bioscience Our preliminary data indicates that the active components of PB
upregulate Nrf signaling and the expression of Nrf dependent genes more than two fold
higher than would be predicted by the adding the responses of each agent individually that
dietary PB in mice increases liver catalase activity and Nrf dependent HMOX gene
expression and decreases markers of inflammation in cultured mouse macrophages In this
project we will expand upon the preliminary data to create an optimized ratio of active
components and test the PB dietary supplement in vivo in a mouse model of aging based on
the measurement of protein homeostasis proteostasis which refers to cellular control of the
concentration location and conformation of individual proteins to achieve stability The ability to
maintain proteostasis is a key outcome in aging and chronic disease research This makes
deficiencies in proteostasis a biomarker associated with aging and also a target for anti aging
strategies such as PB induced Nrf activation Age is a primary risk factor for most chronic diseases Therefore research into
ways to slow the aging process is an area of great importance to both individuals
and society in general In the current project we are developing a new dietary
supplement product that acts at the gene regulation level to increase the bodyandapos s
own cell protective mechanisms and support healthy aging

* Information listed above is at the time of submission. *

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