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Monitoring Pesticide Exposure and Accumulation: An Improved Rapid Identifier for all Pesticide Classes

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44ES024617-02
Agency Tracking Number: R44ES024617
Amount: $981,854.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: PA15-269
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-04-01
Award End Date (Contract End Date): 2020-03-31
Small Business Information
Norwood, MA 02062-2612
United States
DUNS: 076603836
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (508) 439-3446
Business Contact
Phone: (781) 769-9450
Research Institution

Project Summary
The proposed program aims to quantify farmworker exposure to pesticides using Surface Enhanced Raman
SpectroscopySERSand an inexpensive sensor which can also be used for urinalysisAn earlier programsupported by NIEHSprovided reliable results for organophosphateOPand organochlorineOCpesticidesFifty OP and OC pesticides and metabolites were evaluated in the laboratory in the low ppb rangeand
acephate and methyl parathion were detected at farmworker campsIn this programwe will utilize an
innovative SERS sensing element which can also detect triazine pesticidessuch as atrazinesimazine and
cyromazineIn Phase I we developed a glycine coated sensor that stabilized the adsorbed triazine ring
leading to significant signal enhancementThis novel sensor detects triazines down toppbis stable at
temperatures and humidities encountered by farmworkersand can be used for urinalysesA newcombined
sensorto be developed in Phase IIwill measure overpesticides and or metabolites at a small fraction of
the cost of current analytical laboratory methodsIt will provide the NIHparticularly the NIEHS Exposure
Biology programthe means to develop a large data set on daily exposure ingestion of pesticidesThis
approach should allow epidemiological studies and predictions of long term health outcomesCore technology has been demonstratedThe Phase II program is designed to demonstrate the capabilities of
a combined sensor and provide full analytical specificationsfinalize protocols for dosimetryurinecotton wipe
and house dust collection measurementsPrecision and detection limits for pesticides metabolites of
relevance and a thorough interference analysis will be quantitatively definedSystem blind testsstatistical
software optimization using training sets and unknown verifications and field testing with volunteer North
Carolina farmworkers will be performedSpectral dosimetry and urinalysis results will be correlated to worker
activity through worker surveysAn automated system for third party evaluation will be completed in Phase II

* Information listed above is at the time of submission. *

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