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Investigation of a sorbent-based potassium adsorber for the treatment of hyperkalemia induced by traumatic injury and acute kidney injury in austere medicine

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH-16-C-0080
Agency Tracking Number: H161-010-0044
Amount: $149,927.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: DHP16-010
Solicitation Number: 2016.1
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-08
Award End Date (Contract End Date): 2017-04-07
Small Business Information
7 Deer Park Drive, Suite K
Monmouth Junction, NJ 08852
United States
DUNS: 830014077
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Phillip Chan, MD, PhD
 (732) 329-8885
Business Contact
 James Cason
Phone: (732) 329-8885
Research Institution

Hyperkalemia will clearly continue to be a concern in the treatment of combat casualties. The risk of death from hyperkalemia-induced cardiac arrhythmias is significant in the absence of renal replacement therapy (RRT).Rapid evacuation out of Iraq and Afghanistan ensured that most hyperkalemia occurred further up the evacuation chain, thereby limiting the need for non-RRT hyperkalemia treatment options in austere medicine.In future theaters of operation, the military research community must prepare for prolonged field care and extended evacuation times.One implication of the delay is that complications of combat injury, including life-threatening hyperkalemia, will be more frequently managed in the far forward deployed setting.To address this unmet medical need for the military, we plan to develop a forward care medical devices to treat hyperkalemia. In this study two medical devices will be developed, intra-peritoneal dialysis and intra-abdominal mesh packing devices, to reduce systemic potassium levels in austere medical treatment environments.The benefits of our forward care medical device are three-fold: 1) stabilizes hyperkalemia patients to endure prolonged field care and delayed evacuation, 2) is logistically feasible to implement for field use, and 3) expands hyperkalemia treatment options to include transport on aircraft with limited medical capability.

* Information listed above is at the time of submission. *

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