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Development and Demonstration of Virus-Inspired DNA Origami (VIDO) Vaccines

Award Information
Agency: Department of Defense
Branch: Defense Health Program
Contract: W911NF-16-C-0054
Agency Tracking Number: H2-0105
Amount: $999,931.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: OSD11-H01
Solicitation Number: 2014.1
Timeline
Solicitation Year: 2015
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-03-21
Award End Date (Contract End Date): 2018-03-13
Small Business Information
11260 Roger Bacon Drive, Reston, VA, 20190
DUNS: 828881305
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Danley
 (703) 689-9689
 ddanley@parabon.com
Business Contact
 Paula Gawthorp-Armentrout
Phone: (703) 689-9689
Email: parmentrout@parabon.com
Research Institution
N/A
Abstract
Parabon NanoLabs (PNL) has designed and demonstrated the feasibility for a new hybrid vaccine nanostructure that is based upon a DNA origami that can include protein antigens or epitopes, immune stimulators, cell targeting ligands and a transfection plasmid.This approach offers the opportunity for crafting molecularly defined vaccine nanostructures that stimulate a specific primary response that is prolonged by the antigen production by transfected cells.Cell targeting and stimulation may also serve to direct whether an antibody or a cell-mediated response occurs following vaccination. Development of this platform resulted from in silico modeling, and PNL proposes to expand its InSequeo modeling software to create virus-inspired DNA origami (VIDO) vaccines.Based on the availability of recombinant antigens, their gene sequences, and reagents for detection, PNL proposes to demonstrate the first VIDO vaccine using the HIV-1 antigens: 1) HIV-1 Gag as a T cell mediated immune antigen to direct T cell responses against the virus, and 2) an HIV-1 gp140 Env Foldon construct to generate neutralizing antibody (Ab) responses.Results from these studies can be applied to the development of vaccines against other viral and bacterial pathogens that have proved difficult to control through vaccination.

* Information listed above is at the time of submission. *

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