IN ORDER TO FACILITATE THE ULTIMATE PRODUCTION OF A DIAGNOSTIC AND VACCINE FOR HUMAN VIRAL NANB HEPATITIS USING RECOMBINANT DNA TECHNOLOGY, STRATEGIES DESIGNED TO ISOLATE VIRAL NUCLEIC ACID WILL BE INITIATED THROUGH THE PRODUCTION OF ENRICHED RECOMBINANT

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2907
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Chiron Corpon
4560 Horton Street, Emeryville, CA, 94608
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MICHAEL HOUGHTON
 PRINCIPAL INVESTIGATOR
 (415) 655-8729
Business Contact
Phone: () -
Research Institution
N/A
Abstract
IN ORDER TO FACILITATE THE ULTIMATE PRODUCTION OF A DIAGNOSTIC AND VACCINE FOR HUMAN VIRAL NANB HEPATITIS USING RECOMBINANT DNA TECHNOLOGY, STRATEGIES DESIGNED TO ISOLATE VIRAL NUCLEIC ACID WILL BE INITIATED THROUGH THE PRODUCTION OF ENRICHED RECOMBINANT CDNA LIBRARIES AND BY DIRECT RADIO-LABELING STUDIES. IN ADDITION, MONOCLONAL ANTIBODIES WILL BE MADE AGAINST VIRUS PREPARATIONS AND AN IN VITRO SYSTEM FOR PROPAGATING VIRUS INVESTIGATED. AN ASSOCIATION OF REVERSE TRANSCRIPTASE ACTIVITY WITH VIRUS WILL ALSO BE INVESTIGATED. PROGRESS IN THESE AREAS SHOULD LEAD TO THE MOLECULAR CLONING, CHARACTERIZATION, AND RECOMBINANT EXPRESSION OF THE VIRUS GENOME WHICH IN TURN WILL ALLOW DIAGNOSTIC DEVELOPMENT AND

* information listed above is at the time of submission.

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