A NEW APPROACH FOR ANTIGEN PRESENTATION AND POLYVALENT VACCINES IS PROPOSED.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 2909
Amount: $37,095.00
Phase: Phase I
Program: SBIR
Awards Year: 1985
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Chiron Corpon
4560 Horton Street, Emeryville, CA, 94608
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 PABLO VALENZUELA
 PRINCIPAL INVESTIGATOR
 (415) 655-8729
Business Contact
Phone: () -
Research Institution
N/A
Abstract
A NEW APPROACH FOR ANTIGEN PRESENTATION AND POLYVALENT VACCINES IS PROPOSED. EXPERIMENTS ARE DESIGNED TO TEST THE IDEA OF COMBINING THE GENE OF A SECOND IMMUNOGEN WITH THAT OF HEPATITIS B SURFACE ANTIGEN (HBSAG) SUCH THAT THE SECOND IMMUNOGEN IS ASSEMBLED INTO, AND PRESENTED ON, THE SURFACE OF THE HBSAG PARTICLE. THESE ENGINEERED GENES ARE EXPRESSED AS PARTICLES WITH HIGH EFFICIENCY BY TRANSFORMED YEAST OR MAMMALIAN CELLS. USING HYBRID HBSAG-HSV-1GD PARTICLES AS A MODEL WE PROPOSE: A.TO DEVELOP A STANDARD METHOD FOR PURIFICATION OF THE B.TO TEST IN ANIMALS THE ABILITY OF THE HYBRID PARTICLE TO INDUCE ANTIBODIES AGAINST BOTH ANTIGENS, AND C.TO TEST THESE PARTICLES AS A VACCINE IN ANIMALS FOR PROTECTION AGAINST A CHALLENGE WITH THE CORRESPONDING INFECTIOUS AGENTS. ONCE PROVEN SUCCESSFUL, THIS STRATEGY HAS WIDE GENERAL APPLICATION FOR THE MANUFACTURE OF SAFE AND EFFICACIOUS VACCINES FOR HUMAN USE.

* information listed above is at the time of submission.

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