Preparation of Vaginal Lactobacillus Suppository

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$742,790.00
Award Year:
1996
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 AI36021-1,
Award Id:
24777
Agency Tracking Number:
24777
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3941 Ryan Street, Lake Charles, LA, 70605
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gerald Chrisope
(318) 479-1000
Business Contact:
() -
Research Institute:
n/a
Abstract
We will develop a commercially available vaginal suppository containing a hydrogenperoxide-producing strain of Lactobacillus for use in colonization of the vagina. In this project, a strainof Lactobacillus will be identified based on adherence to vaginal epithelial cells, hydrogen peroxideproduction, and growth characteristics. Methods for strain preservation and maintenance of viability,biochemical, physiologic and genetic characteristics during large scale production will be optimized. Theeffect of suppository delivery formats and components including various cream and gel bases, growthor nutritional additives on successful bacterial rejuvenation, adherence and hydrogen peroxide productionwill be investigated.

* information listed above is at the time of submission.

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