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Soft Bio-Interfaces for Physiological Sensing and Modulation

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: D16PC00091
Agency Tracking Number: D153-001-0094
Amount: $149,990.04
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SB153-001
Solicitation Number: 2015.3
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-04-12
Award End Date (Contract End Date): 2017-03-08
Small Business Information
17217 Waterview Pkwy
Dallas, TX 75252
United States
DUNS: 080158943
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dane Grasse
 (920) 227-7520
Business Contact
 Walter Voit
Phone: (469) 450-1849
Research Institution

We will demonstrate penetrating peripheral recording and stimulating devices using engineered low cure stress softening polymer substrates. Polymers can be implanted at moduli of more than 1 GPa and soften toward the modulus of tissue. Neural interfaces allow for delivery of a large amount of information, but current microstimulators or microrecorders fail chronically or are poorly suited for interfacing with small biological structures, such as sensory peripheral nerves. We discuss chronic device failure through design of both materials and devices to overcome various failure mechanisms. We demonstrate the effects of softening vagus nerve interfaces and penetrating, coiling cochlear implants. We will demonstrate spinal stimulators that reduce inflammation and tissue response and behave in a manner similar to ball electrodes for use in understanding long-term muscle plasticity. We demonstrate softening peripheral neural interfaces for modulating sensory and motor input toward closed-loop feedback for prosthetics. We will support the neuroscience research community and the wounded warrior with devices toward future clinical work based on this feasibility study.

* Information listed above is at the time of submission. *

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