Cytometer on a Chip

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$70,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
NAS9-03009
Award Id:
63263
Agency Tracking Number:
024034
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
111 Roberts Street, Suite K, East Hartford, CT, 06108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Salvador M. Fernandez
(860) 528-9737
fernandez@ciencia.com
Business Contact:
Arturo Pilar
Business Official
(860) 528-9737
apilar@ciencia.com
Research Institution:
n/a
Abstract
The objective of the proposed effort is to develop a novel technology that will provide a unique and powerful alternative to conventional flow cytometry. This new system, which we call a cytometer on a chip will spatially sort cells on a microarray chip based on the presence of specific cell surface receptors or other surface features. Detection and quantitation is accomplished with grating-coupled surface plasmon resonance imaging (GCSPR). This is a label-free detection technology that obviates the need for fluorescent or other types of labels. This feature and the fact that the technology is amenable to miniaturization and consumes very little power, makes the cytometer on a chip system ideally suited to the assessment of immune function in space and to cost-effective, rapid, on site clinical diagnostics. In the Phase I we will evaluate the feasibility of the proposed concept with a lymphocyte model system and we will evaluate the system?s capability to separate cell populations and to distinguish between activation state.

* information listed above is at the time of submission.

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