Integrated Protein/Nucleic Acid Microarray CB Detector

Award Information
Agency:
Department of Defense
Branch
Defense Threat Reduction Agency
Amount:
$100,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase I
Contract:
DTRA01-03-P-0191
Agency Tracking Number:
T031-0146
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CIENCIA, INC.
111 Roberts Street, Suite K, East Hartford, CT, 06108
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
616818738
Principal Investigator:
Salvador Fernandez
President
(860) 528-9737
fernandez@ciencia.com
Business Contact:
Arturo Pilar
Vice President
(860) 528-9737
apilar@ciencia.com
Research Institution:
n/a
Abstract
The objective of the proposed program is to develop a portable, low-cost, label-free (reagentless), microarray system capable of near real-time simultaneous detection and identification of multiple analytes (bacteria, viruses, spores, toxins) with highsensitivity and low false alarm rate. Notably, the system will be capable of detection/identification of agents on the basis of protein and/or nucleic acid recognition. The system will consist of a disposable biosensor chip and an optical reader devicewith an integrated sample collector. Detection is based on a proprietary optical transduction technology known as grating-coupled surface plasmon resonance imaging. In the Phase I effort we will demonstrate the operation of the collector anddetection/identification components and perform a preliminary specification and design of a system to be built and tested in a Phase II effort. The proposed technology is dual use. Potential applications include hospitals, where nosocomial infections mayarise; large buildings where accidental contamination with mold spores, Legionella and other pathogens may create health hazards; recreational water and drinking water supplies where waterborne pathogens are a great concern, and the food industry, wherethere is a need for sensitive methods for on-line and real-time detection of pathogens.

* information listed above is at the time of submission.

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