Integrated Protein/Nucleic Acid Microarray CB Detector

Award Information
Agency: Department of Defense
Branch: Defense Threat Reduction Agency
Contract: DTRA01-03-P-0191
Agency Tracking Number: T031-0146
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
111 Roberts Street, Suite K, East Hartford, CT, 06108
DUNS: 616818738
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Salvador Fernandez
 President
 (860) 528-9737
 fernandez@ciencia.com
Business Contact
 Arturo Pilar
Title: Vice President
Phone: (860) 528-9737
Email: apilar@ciencia.com
Research Institution
N/A
Abstract
The objective of the proposed program is to develop a portable, low-cost, label-free (reagentless), microarray system capable of near real-time simultaneous detection and identification of multiple analytes (bacteria, viruses, spores, toxins) with highsensitivity and low false alarm rate. Notably, the system will be capable of detection/identification of agents on the basis of protein and/or nucleic acid recognition. The system will consist of a disposable biosensor chip and an optical reader devicewith an integrated sample collector. Detection is based on a proprietary optical transduction technology known as grating-coupled surface plasmon resonance imaging. In the Phase I effort we will demonstrate the operation of the collector anddetection/identification components and perform a preliminary specification and design of a system to be built and tested in a Phase II effort. The proposed technology is dual use. Potential applications include hospitals, where nosocomial infections mayarise; large buildings where accidental contamination with mold spores, Legionella and other pathogens may create health hazards; recreational water and drinking water supplies where waterborne pathogens are a great concern, and the food industry, wherethere is a need for sensitive methods for on-line and real-time detection of pathogens.

* Information listed above is at the time of submission. *

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