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Cytometer on a Chip

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNJ04JA14C
Agency Tracking Number: 024034
Amount: $600,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: B2.03
Solicitation Number: N/A
Solicitation Year: 2002
Award Year: 2004
Award Start Date (Proposal Award Date): 2003-12-01
Award End Date (Contract End Date): 2005-12-01
Small Business Information
111 Roberts Street, Suite K
East Hartford, CT 06108-3653
United States
DUNS: 000000000
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Salvador M. Fernandez
 Principal Investigator
 (860) 528-9737
Business Contact
 Arturo Pilar
Title: Business Official
Phone: (860) 528-9737
Research Institution

The Cytometer on a Chip will provide a powerful alternative to conventional flow cytometry. This system spatially sorts cells on a microarray chip based on the presence of specific cell surface markers. Detection is accomplished with grating-coupled surface plasmon resonance imaging (GCSPRI). This is a label-free detection technology that eliminates the need to fluorescently label the cells, as is necessary with conventional flow cytometry. This innovation will reliably measure cellular composition while avoiding the limitations of traditional flow cytometry. Since the cells are run over the chip surface, there is no requirement for the stringent optical alignments that are so essential to fluorescence-based cytometry. Moreover, the system does not require the narrow orifice of the flow cell that is used by most traditional cytometers, so is far less susceptible to clogging or to flow disturbances caused by accumulation of adsorbed proteins or air bubbles. Finally, it eliminates the complexity, mass and power associated with laser and detection systems traditionally used in flow cytometry. These features, and the fact that the technology is amenable to miniaturization and low power operation, make the cytometer on a chip system ideally suited to the assessment of immune function in space and to cost-effective, rapid, on site clinical diagnostics.

* Information listed above is at the time of submission. *

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