Microarray System for Phenotypic and Functional Cytometry

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$123,719.00
Award Year:
2007
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI073007-01A1
Award Id:
85303
Agency Tracking Number:
AI073007
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CIENCIA, INC., 111 ROBERTS ST, STE K, EAST HARTFORD, CT, 06108
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
616818738
Principal Investigator:
ERNEST GUIGNON
(860) 528-9737
EFG@CIENCIA.COM
Business Contact:
ARTURO PILAR
() -
apilar@ciencia.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of infection, inflammation, asthma, au toimmune disease, and neoplasia. This system will be a microarray-based bioassay platform that specifically captures distinct cell types and soluble macromolecules from a patient's blood sample onto spatially separate regions on a biosensor chip. Initial c apture of macromolecules and cells can be quantified to assess the presence of specific subpopulations of leukocytes, cytokines, antibodies and other immunologically relevant molecules. Subsequent culture of the captured cells under different conditions ca n be used to measure the production of specific cell products in real time to assess immune cell functional capacities. The technology allows for highly parallel measurements that result in the capability to perform hundreds of individual functional cellul ar assays simultaneously without the use of molecular labels. The system will enable assessment of patients' immune capacity in near-real time using microliter-scaled samples of blood readily harvested with minimally invasive procedures (e.g., fingerstick capillary blood sampling). Such real-time measurements will be crucial for the ongoing monitoring of disease progression as well as the evaluation of prophylactic treatments and therapeutic manipulations that sustain and support immune mechanisms. This pro ject will develop tools that will enable improved diagnostics for autoimmune diseases and for infectious diseases.

* information listed above is at the time of submission.

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