DYE-LESS NADH FLUORIMETER

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,713.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19400
Agency Tracking Number:
19400
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
3035 Dryden Road, Dayton, OH, 45439
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Bob W Stewart
(513) 296-0513
Business Contact:
() -
Research Institution:
n/a
Abstract
THE GOAL OF THE RESEARCH IS TO DEVELOP A DYE-LESS, MULTI-REFERENCE WAVELENGTH NADH FLUORIMETER. THE SYSTEM, UTILIZING AN INEXPENSIVE NITROGEN LASER AS A PUMP, WILL USE AN OPTICAL PARAMETRIC OSCILLATOR INSTEAD OF A DYE LASER TO GENERATE THE REFERENCE WAVELENGTH. THE REFERENCE WAVELENGTH CAN BE ALTERED BY SIMPLY PRESSING A BUTTON, INSTEAD OF SWITCHING THE DYE AS IN THE CURRENT NADH FLUORIMETER. THE RESULTING SYSTEM IS MORE COMPACT, LESS EXPENSIVE, AND MORE RELIABLE THAN THE CURRENT NADH FLUORIMETER. THE ABILITY TO RAPIDLY ALTER REFERENCE WAVELENGTHS COULD POSSIBLY BE EXPLOITED IN ORDER TO EXPAND THE APPLICATION OF NADH FLUORIMETRY TO AREAS WHERE OTHER ARTIFACTS MAY BE PRESENT. APPLICATIONS TO DOSIMETRY IN PHOTODYNAMIC THERAPY (PDT) AND HYPERTHERMIA AS WELL AS DIAGNOSIS OF MELANOBLASTOMA WILL BE EXPLORED IN THE FUTURE.

* information listed above is at the time of submission.

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