Starch-Entrapped Microspheres [Nutrabiotix Fiber] for Gut Health

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43DK088525-01
Agency Tracking Number: DK088525
Amount: $247,561.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NIDDK
Solicitation Number: PHS2010-2
Small Business Information
DUNS: 826373792
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 () -
Business Contact
Phone: (765) 427-6377
Research Institution
DESCRIPTION (provided by applicant): To establish the proof of concept that Nutrabiotix fiber is safe and well tolerated, promotes gut health by increasing production of short chain fatty acids and changes colonic microbiota composition in favor of bifidobacteria, improves bowel habit and increase in stool weight. To this end, we will conduct a randomized, double blind, controlled, dose ranging, 3 arm trial in 120 healthy subjects comparing two doses of the Nutrabiotix fiber to psyllium fiber. PUBLIC HEALTH RELEVANCE: The completion of this project will prove the efficacy and tolerability of Nutrabiotix fiber in humans and will form the basis of commercializing a well tolerated natural carbohydrate product with targeted delivery to the colon that promotes gut health and potentially, prevents and treats colonic diseases where changes in the gut microbiota and/or colonic milieu play a key pathogenic role.

* Information listed above is at the time of submission. *

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