Laser Source for 2-Photon-Excited Confocal Microscopy

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$407,437.00
Award Year:
1997
Program:
SBIR
Phase:
Phase II
Contract:
1 R43 RR10054-01,
Agency Tracking Number:
29671
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Clark/mxr, Inc.
Box 370, 7300 W Huron River D, Dexter, MI, 48130
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Yang Pang
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
We will develop a compact, robust, and user-friendly laser Source for 2-photon excitation in lasermicroscopy. The use of 2-photon excitation in confocal microscopy offers a number of advantages forphysiology; however, the use of this technique is currently limited due to the specialized nature offemtosecond duration pulses. 100- femtosecond pulses from a modelocked solid-state laser operating a1.3 microns will be frequency-doubled to generate wavelength tunable ultrashort pulses in the desirearound 650 nanometers. A version of the modelocked laser which is pumped by an array of laser diodesdesigned and built to reduce the size and enhance the stability and reliability of the source. Theresources of 100-femtosecond pulses at the wavelengths which are needed, nor has there been a repone ofemtosecond laser at any wavelength. With a source having the required characteristics it will be pobase of existing and future scanning microscopes for 2-photon excitation.

* information listed above is at the time of submission.

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