Identification of Immunogenic Components of Flavobacterium Psychrophilum for a CWD Vaccine

Award Information
Agency: Department of Agriculture
Branch: N/A
Contract: 2001-33610-10373
Agency Tracking Number: 2001-00378
Amount: $69,582.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Clear Springs Foods, Inc.
P. O. Box 712, Buhl, ID, 83316
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Scott LaPatra
 (208) 543-3456
 scottl@clearsprings.com
Business Contact
 John MacMillan
Title: Vice President, Research & Environmental
Phone: (208) 543-3456
Research Institution
N/A
Abstract
Coldwater disease (CWD), caused by Flavobacterium psychrophilum, results in severe losses to salmonid aquaculture worldwide. In recent years, this disease has had a significant economic impact on commercial, Federal and State aquaculture facilities in the U.S. Immunization against this disease would provide the most benefit to producers, and although significant protection has been observed under laboratory conditions, no commercial vaccines exist. This is likely due to virulence differences observed among F. psychrophilum isolates. This Phase I study will evaluate and identify immunogenic antigens of F. psychrophilum and determine the role of virulence-associated proteins in conferring antibody- mediated protection. Limited data exists on the immune response of fish to F. psychrophilum, but is considered essential to developing a vaccine to CWD. Therefore, this study will 1) evaluate antibody responses to F. psychrophilum following immunization via injection and immersion routes, 2) identify the major bacterial protein components to which an antibody response is generated, and 3) determine the importance of these antigens in protection from pathogen challenge. This will greatly increase our understanding of the immune response to this disease and provide a foundation for the development of vaccine in Phase II studies that would greatly benefit the aquaculture industry.

* information listed above is at the time of submission.

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