Award Information
Department of Health and Human Services
Award Year:
Phase I
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Small Business Information
5001 BAUM BLVD, STE 720, Pittsburgh, PA, 15213
Hubzone Owned:
Minority Owned:
Woman Owned:
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() -
Business Contact:
(412) 688-8970
Research Institute:
In 1992 alone, there were 516,255 births to teenage mothers. Unaware of the importance of well-child care and immunizations, adolescent mothers often do not bring their children for regular check ups. Their children are at great risk for poor medical and developmental outcomes. The mothers too frequently have non-adaptive parenting skills, repeat pregnancies, and do not finish school. There is a need to provide education specifically created for these young women. To address this need, we propose to develop and evaluate, Mother's Helper, a new, interactive educational tool designed especially for adolescents. This multimedia CD-ROM will provide teen mothers with information on basic infant care skills and emphasize their adaptation to parenting responsibilities. Potential benefits of the program are: 1) improved compliance with health care visits and immunizations, 2) prevention of repeat teen pregnancies, and 3) increased flexibility in teen parenting attitudes. Phase I evaluates utility and technical feasibility by producing part f the curriculum designed for the first well-baby visit. We will assess the software with respect to user satisfaction and effectiveness in delivering information. Phase II will expand the software to cover the first year of a child's life and includes an efficacy study of the final product. Currently, we are in Phase I and are evaluating the Mother's Helper software. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 376 --PROJECT NUMBER......1 R43 HD35030-01 INVESTIGATOR NAME/ADDRESS FY 97 STRICKLAND, DOROTHY C IRG/INTRAMURAL UNIT..ZRG5 VIRTUAL REALITY AIDS AWARD AMOUNT......... $99,798 500 WEST CHATHAM STREET APEX, NC 27602 PERFORMING ORGANIZATION: VIRTUAL REALITY AIDS TITLE EVALUATING VIRTUAL REALITY INSTRUCTION FOR AUTISM ABSTRACT: DESCRIPTION: The broad long term objectives of the project are to develop a virtual reality instructional aid for children with autism and document efficacy. The specific aims are: 1) build a prototype of a low cost commercially feasible virtual reality system that can be used in the classroom, 2) demonstrate the system's instructional potential to recognize the spoken names for common objects in their environment, 3) demonstrate that stills [sic] learned in the virtual world are generalized to the real world. The learning environment control afforded by virtual reality may allow improved skill training and communication assistance for individuals with mental retardation and developmental disorders, communication disorders, and other mental disorders. The research design and methods for achieving the goals are: (1) Children in the school system who have been diagnosed with autism will be chosen, (2) A low cost virtual reality system will be constructed from off-the-shelf equipment, (3) Software will be designed, coded, and tested to utilize unique features provided by virtual reality treatment, such as controlled input and feedback of the child's actions, (4) This instructional program will be tested using n, multiple baseline across subjects design, with generalization probes testing for generalization across instances of a concept and generalization to real world objects in the classroom. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 377 --PROJECT NUMBER......1 R43 HD35044-01 INVESTIGATOR NAME/ADDRESS FY 97 BALLIET, RICHARD IRG/INTRAMURAL UNIT..ZRG4 ARTSCO, INC AWARD AMOUNT......... $99,317 375 WILLIAM PITT WAY PITTSBURGH, PA 15238 PERFORMING ORGANIZATION: ARTSCO, INC. TITLE 7 SPEED COASTER/BRAKE HUB SYSTEM FOR MANUAL WHEELCHAIRS ABSTRACT: DESCRIPTION: (Adapted from applicant's abstract) This proposal describes the first internally-geared, 7-Speed/Coaster-Brake Hub System for Manual Wheelchairs {MWCHS} with significant commercial potential since it can be retrofitted to most manual wheelchairs {MWC}to increase the wheelchair's function. The MWCHS has a total gear range of 284% and provides a mechanical advantage similar to the 10-Speed derailleur/sprocket system found on most bicycles. The general populations who will benefit from the MWCHS include: marginal pushers, persons with upper extremity pain and persons who wish to travel over long periods of time or over long distances. The MWCHS allows the operator the choice of either: 1. normal Single/Fixed Gear Travel, accessible by direct rotation of tires or (optional) tire handrims; or 2. electronically Shifted 7-Speed and Differential Coaster- Brakes, accessible by second set of handrims with forward or backward motion, respectively. Four primary areas of the research plan remain to be completed in a Phase I: 1. completion of MWCHS construction; 2. evaluation of user feedback, 3. preliminary testing of physiological efficiency; and 4. MWCHS fatigue testing. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 378 --PROJECT NUMBER......1 R43 HD35048-01 INVESTIGATOR NAME/ADDRESS FY 97 JOSIMOVICH, JOHN B IRG/INTRAMURAL UNIT..ZRG2 BIODIAGNOSTICS, INC AWARD AMOUNT......... $100,000 100 INMAN ST CAMBRIDGE, MA 02139 PERFORMING ORGANIZATION: BIODIAGNOSTICS, INC. TITLE CONTRACEPTION BASED ON LACTATIONAL AMENORRHEA ABSTRACT: In the United States, over two million women breastfeed their babies each year. World-wide, between 50 and 100 million breastfeed annually. In some countries, as many as 90% of the women breastfeed for longer than a year. Lactational amenorrhea (LAM) causes infertility. This period of infertility contributes to decreased birth rates for at least 50% of the 100 million women who deliver annually. LAM is an important factor in limiting population growth. The objective of this project is to define the hormone parameters associated with lactational amenorrhea with the purpose of facilitating family planning. We seek a method of delineating the boundaries between the infertile and fertile states. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 379 --PROJECT NUMBER......1 R43 HD35394-01 INVESTIGATOR NAME/ADDRESS FY 97 HURLEY, J MICHAEL IRG/INTRAMURAL UNIT..ZRG5 5 PRIME-> 3 PRIME, INC AWARD AMOUNT......... $100,000 5603 ARAPAHOE AVE BOULDER, CO 80303-1332 PERFORMING ORGANIZATION: FIVE PRIME-THREE PRIME, INC. TITLE IMPROVED CHROMOSOMAL GENE TARGETING IN BACTERIA ABSTRACT: Directed repair or replacement of chromosomal gene sequences with cloned wild type or mutant DNA, also known as gene targeting, remains a technically challenging task. Although methods have been described for gene targeting in bacteria, most require specialized skills or material and often are time-consuming and laborious in practice. Linear DNA molecules possessing chi (khi) sites (5'-GCTGGTGG-3') participate in gene targeting replacement reactions through homologous recombination with the bacterial chromosome at much higher frequencies than DNAs lacking them. This project's goal is to develop a novel set of cloning vectors for gene targeting and gene knockout in E. coli and related enteric bacteria. Cloning vectors with multiple khi sites will be constructed and functionally tested for stimulation of gene targeting in vivo. Parameters to be evaluated address both the nature of the targeting DNA molecule and any influence that differ chromosomal target sites may have. A kit then will be developed enabling scientists to quickly and easily carry out gene targeting reactions, and should find widespread utility, for example, in mutating virulence genes from pathogenic bacteria. Longer term goals will be to apply this strategy to directed gene replacements in more distantly-related bacteria and eukaryotic systems.

* information listed above is at the time of submission.

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