Membrane Oxygenators for Enhancing Bioreactors

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$99,900.00
Award Year:
1995
Program:
SBIR
Phase:
Phase I
Contract:
1 R43 GM54385-01,
Agency Tracking Number:
29473
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Compact Membrane Systems, Inc.
325 Hampton Road, Wilmington, DE, 19803
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Stuart Nemser
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
The investigators will develop a new class of perfluoropolymers with exceptionally high oxygen fluxmembranes for enhanced bioreactor performance. Propagation of animal cells for biopharmaceuticals iswidespread along with optimization of environmental constraints and procedures to increase bioreactooxygen availability limits bioreactor cell culture production. Sparging is the choice method to aerawith sensitive animal cells sparging can be counterproductive. Entertainment at liquid/gas interfacecells. Microporous hollow fibers to introduce oxygen also causes shear damage to animal cells. Animaattach to microporous fibers and impede gas transfer. The copolymer of perfluoro-dimethyl-dioxole (Ptetrafluoroethylene (TFE) display membrane permeabilities 40 times higher than conventional membranerubber). The PDD-TFE organophobic and hydrophobic surface should discourage cell surface attachmentinvestigators will make both hollow fiber and flat sheet oxygenator modules which will be evaluatedin bioreactors to determine their oxygen transfer rates, non-plugging characteristics and their abilhaving enhanced oxygen uptake rates.

* information listed above is at the time of submission.

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