Enhanced Long-Term Care of Severe Respiratory Failure

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$1,010,459.00
Award Year:
2004
Program:
SBIR
Phase:
Phase II
Contract:
2R44HL064528-02
Agency Tracking Number:
1R43HL064528-01
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
COMPACT MEMBRANE SYSTEMS, INC.
325 WATER STREET, WILMINGTON, DE, 18904
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
STUART NEMSER
(302) 999-7996
stuart.nemser@compactmembrane.com
Business Contact:
NADINE CRAGG-LESTER
(302) 999-7996
NLESTER@COMPACTMEMBRANE.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Current management of acute respiratory distress syndrome (ARDS) is suboptimal. Arteriovenous carbon dioxide removal (AVCO2R) combined with mild oxygen ventilation has shown promise. AVCO2R is mild pumpless technique using low-pressure drop membrane oxygenators, which reduces labor, cost, complexity and patient stress. While AVCO2R works for short durations, ARDS therapy must operate continuously for weeks. Phase I successfully demonstrated CMS non-porous membranes significantly enhance AVCO2R membrane long term wet-out resistance while maintaining carbon dioxide removal membrane modules fluid dynamics. Working closely with University of Texas (UT) we completed short-term in-vivo testing on 10 sheep using UT sheep model. In-vivo results showed CMS AVCO2R system compared favorably to control. Long term in-vivo testing further supported CMS new membrane technology. Phase II will build upon Phase I feasibility success and first optimize membrane module fabrication. Working with UT we will do extensive in-vitro testing and then perform numerous (40+) long-term sheep studies. CMS has numerous industrial partners assisting in Phase II system fabrication and subsequent evaluation. These relationships will help Phase II plus identifying appropriate commercialization partners.

* information listed above is at the time of submission.

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