New DNA/RNA Sequencer for Rapid Assessment of Exposure to Infectious Agents

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: DAAD19-01-C-0059
Agency Tracking Number: C011-0107
Amount: $69,993.00
Phase: Phase I
Program: SBIR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
325 Water Street, Wilmington, DE, 19804
DUNS: 937936946
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Nina Lamba
 Dir. of Biomedical Techno
 (302) 999-7996
Business Contact
 Stuart Nemser
Title: President
Phone: (302) 999-7996
Research Institution
The threat of terrorist or military attack using biological or chemical warfare agents is one of the largest concerns to U.S. military forces. Development of defense initiatives that can be implemented to decontaminate personnel, equipment and buildingsare required to counter the effects of such an attack. A series of dendrimer-quaternary ammonium compound (QAC) biocides have been identified that demonstrate potent antimicrobial activity against bacteria. These materials are more than 100 times moreeffective at killing E.coli than a comparable amount of free QAC. It is anticipated that these materials will be able to decontaminate chemical agents also.The goal of the proposed work is to develop these biocides for military defense applications. Materials will be synthesized, characterized and tested for antimicrobial activity. Optionally, we will explore the efficiency of these materials against chemicalagents. We expect these materials to be effective against warfare agents, but non-destructive to equipment, electronics etc. These materials can be applied as a powder, in solution, or immobilized onto polymers, enhancing utility in pre-event installationmeasures as well as post-event decontamination.Successful development of these materials would provide a broad spectrum agent for the neutralization and decontamination of biological and chemical warfare agents. These agents could be used both to protect personnel and installations in the event ofexposure, and as decontamination agents during clean-up. These materials are not expected to cause severe damage to materials of construction of buildings, equipment etc. The ability to use these materials in a number of forms will allow their use as airfilters, solutions, aerosols, garments, ointments, water purification etc. More broadly, compounds and materials displaying biocidal activity will have commercial applicability to private sectors where prevention of biofilms is desired, includinghealthcare,. Polymers containing these biocidal agents will have utility wherever prevention of bacterial adhesion and colonization is required, e.g. protective clothing, food preparation areas, medical devices, air filtration systems, waterlines, etc.

* Information listed above is at the time of submission. *

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