ANTIMICROBIAL POLYMERS FOR MEDICAL APPLICATION

Award Information
Agency:
Department of Health and Human Services
Amount:
$100,000.00
Program:
SBIR
Contract:
1R43HL069542-01
Solitcitation Year:
N/A
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2002
Phase:
Phase I
Agency Tracking Number:
HL069542
Solicitation Topic Code:
N/A
Small Business Information
COMPACT MEMBRANE SYSTEMS, INC.
325 WATER STREET, WILMINGTON, DE, 18904
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
N/A
Principal Investigator
 HANS GLASER
 () -
Business Contact
 STUART NEMSER
Phone: (302) 999-7996
Email: SNEMSER@COMPACT.MEMBRANE.COM
Research Institution
N/A
Abstract
A new class of antimicrobials based on dendrimer technology has been identified and shown to possess potent biocidal activity. Laboratory evaluation of these polycationic dendrimers has shown that they are more than 100 times more effective than a comparable amount of free quaternary ammonium compound at killing Esherichia coli. Potent activity against Staphylococcus aureus has also been demonstrated. These antimicrobial dendrimers have also been successfully immobilized on to linear polyurethanes. These non-leaching biocidal polymers demonstrated antibacterial activity, even though the degree of substitution was limited to approximately 3 weight percent. We propose to explore other methods to increase and optimize the level of incorporation of the dendrimer onto the polymer backbone. Following synthesis, materials will be tested for antimicrobial activity. It is expected that defining new techniques to covalently graft these compounds onto polymers will enhance the performance of these materials, and provide the basis for antimicrobial polymers and textiles for a wide range of applications, including medical devices (catheters, wound dressings, surgical drapes), antimicrobial air filters, and dental unit waterlines.

* information listed above is at the time of submission.

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