Novel Pharmaceutical Solvent-Water Separation System

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$863,147.00
Award Year:
2007
Program:
SBIR
Phase:
Phase II
Contract:
2R44GM071093-02
Award Id:
76293
Agency Tracking Number:
GM071093
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
COMPACT MEMBRANE SYSTEMS, INC., 335 WATER STREET, NEWPORT, DE, 19804
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
808898894
Principal Investigator:
STUARTNEMSER
(302) 999-7996
SNEMSER@COMPACTMEMBRANE.COM
Business Contact:
LOUISDINETTA
() -
rtierney@compactmembrane.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): In Phase I we exceeded all key objectives. We demonstrated in both pervaporation and vapor separation the combination of high membrane permeation and high membrane separation when evaluating isopropyl alcohol (IPA)-Wate r separation. Membrane stability, which had been concern of reviewers, was shown to be excellent and far superior to other commercial membranes. CMS membranes were shown to be stable up to 130'C and over the whole compositional operating range. Economic ev aluations showed the CMS membranes to have in excess of 80% capital savings compared to existing drying processes. In addition to work on IPA-water, two other pharmaceutical solvents were successfully evaluated. Leaching studies have shown the CMS membrane s to be stable. Based on results and commercialization analysis the CMS system is seen as a platform technology. Significant opportunities exist in pharmaceutical solvent recovery enhancing chemical reactions, chemical industry solvent recovery, manufactur e of fuel grade ethanol and stabilizing industrial esters. With many opportunities, a large number of industrial and pharmaceutical companies as well as leading researchers have committed to actively participate in this program. This participation will enh ance overall chances for commercialization. In Phase II we will first fabricate high flux composite membrane modules. Then we would focus our demonstration on IPA-water systems operating in pervaporation (PV) mode. Focus will be on PV since this is the sim plest system for the end user. Once successful basic data on IPA-water in PV is obtained we will expand the evaluation to other pharmaceutical solvents and also evaluating membranes in the vapor separation mode. Additional upgrades will include modeling an d system design to enhance overall purification; long term testing plus extended solvent leaching tests; develop enhanced membrane modules using commercial hollow fiber supports; building large skid for field testing and expanding our economic evaluation t o show superior performance to alternative drying routes. Throughout this Phase II we will work closely with our industrial partners. This program develops a low cost, simple, process to recover pharmaceutical solvents. This will encourage solvent reuse wh ich is environmentally attractive and cost effective. The process will also keep potential biological contaminants out of the environment.

* information listed above is at the time of submission.

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