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Miniature Mass Spectrometer for Peptide Sequencing and Mobile Coupling with Separation Techniques

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911SR-16-C-0053
Agency Tracking Number: A16A-012-0019
Amount: $149,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A16A-T012
Solicitation Number: 2016.0
Timeline
Solicitation Year: 2016
Award Year: 2016
Award Start Date (Proposal Award Date): 2016-09-09
Award End Date (Contract End Date): 2017-03-08
Small Business Information
1101 McKay Drive
San Jose, CA 95131
United States
DUNS: 124291050
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 William Yang
 (408) 512-5928
 wyang@bayspec.com
Business Contact
 Eric Bergles
Phone: (408) 512-5928
Email: ebergles@bayspec.com
Research Institution
 Pacific Northwest National Laboratory
 Keqi Tang
 
902 Battelle Blvd \N
Richland, WA 99354
United States

 (509) 371-6542
 Federally funded R&D center (FFRDC)
Abstract

Using advanced ion optics that was developed by Pacific Northwest National Laboratory (PNNL), BaySpec will develop a prototype of portable mass spectrometer (less than 40 lb. and 300W) with continuous atmospheric pressure inlet that is fully capable of uninterrupted on-line sampling from an ambient environment. The continuous nature of the inlet ensures full compatibility with separation techniques such as liquid chromatography. The default modes of ionization will be microelectrospray or nanospray and thermal desorption electrospray, but the atmospheric pressure inlet with externally heated inlet capillary can be easily coupled with many different ambient ionization techniques The design of the prototype will be based on unique proprietary combination of ion optics and 2D ion trap. Complex radio-frequency focusing invented by PNNL and licensed to Bayspec will be used to transport ions from atmospheric pressure through novel set of conductance limits into the mass analyzer. Continuous inlet and differential pumping is the industry standard for large research grade mass spectrometers and its utilization for miniature mass spectrometry maintains the known advantages. In terms of limit of detection and compatibility with separation techniques, the continuous inlet design is superior to other technical solutions such as discontinuous atmospheric pressure inlet.

* Information listed above is at the time of submission. *

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