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Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized Patients

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41GM119871-01A1
Agency Tracking Number: R41GM119871
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 400
Solicitation Number: PA15-270
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-05-01
Award End Date (Contract End Date): 2018-08-31
Small Business Information
29001 CEDAR RD STE 326
Cleveland, OH 44124-6501
United States
DUNS: 079841470
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (512) 271-7167
Business Contact
Phone: (832) 248-7179
Research Institution
AUSTIN, TX 78759-5316
United States

 Nonprofit College or University

Project Summary Abstract
This proposal presents Phase of the plan of Mercury Biomed LLC for commercializing the new and
innovative WarmSmart technology to more effectively keep patients warm during anesthetized surgery The
WarmSmart technology is based on IP licensed from the University of Texas at Austin who is the academic
partner for this STTR proposal WarmSmart embodies several breakthrough concepts in bioheat transfer to
manage core temperature We anticipate a cost competitive technology that will offer equivalent or superior
thermal performance than existing technologies with multiple unique advantages and that will be much more
convenient simple and safe to use
The most widely applied existing technology for keeping patients warm during surgery uses heating applied
over large areas of the body surface via forced convection of hot air through an outer bag placed onto the
patient A recent comprehensive study shows that this technology failed to maintain patients above the
minimum acceptable core temperature throughout surgeries in of the cases plus it occupies large areas of
the body surface placing unnecessary restrictions on access to the patient during surgery WarmSmart
requires access to only the hands and feet where uniquely high rates of blood flow can occur through glabrous
skin constituting the bodyandapos s already existing high performance heat flow pathway between the surface and the
core Not only does WarmSmart add heat more effectively to combat drops in core temperature in doing so it
blocks and reverses the primary heat loss process caused by anesthesia making it doubly effective
The project will have two specific aims to prepare for conducting clinical trials with WarmSmart in Phase
In SA an existing thermoelectric powered device available to Mercury will be redesigned and reengineered
to meet the minimum of W heating capacity The heart of the existing technology is a thermoelectric energy
source that can provide a water flow to heating pads applied to the hands and feet at precisely regulated
temperatures Enhancements will include a more efficient design for the water flow heat exchangers and a
higher flow capacity water pump New water flow pads will incorporate state of the art heat exchanger design
principles A new operator interface will be created based on input from our advisory panel of anesthesiologists
to ensure practical acceptance of WarmSmart In SA working prototypes of WarmSmart will be designed
fabricated and experimentally verified for thermal performance UT will conduct scientific and initial human
heat transfer analysis and Mercury will perform a point verification protocol for final refinement in
preparation for clinical trials and subsequent FDA registration The deliverable outcome is ten tested
WarmSmart devices that can be applied in clinical trials with our medical collaborators at Cleveland Clinic Project Narrative
WarmSmart is a new concept in devices for perioperative warming of anesthetized patients to more
effectively keep them above the safe minimum core body temperature and to be more compatible for use with
surgical procedures WarmSmart will make the management of anesthesia safer and more convenient and will
provide better results for patient recovery from surgery

* Information listed above is at the time of submission. *

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