PREPARATION OF MONOCLONAL ANTIBODIES TO PLANT-DERIVED OLIGO- AND POLYSACCHARIDES

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
6982
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Complex Carbohydrate Corp
2351 College Station Rd #512, Athens, GA, 30605
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR MICHAEL G HAHN
(404) 546-7797
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THIS RESEARCH PROJECT IS TO GENERATE MONOCLONAL ANTIBODIES THAT RECOGNIZE DEFINED EPITOPES ON OLIGO- AND POLYSACCHARIDES OF PLANT ORIGIN. SUCH ANTIBODIESWILL BE USEFUL FOR PURIFYING PLANT-DERIVED OLIGO- AND POLYSACCHARIDES, PROVIDING STRUCTURAL INFORMATION ABOUT THE CARBOHYDRATES TO WHICH THE ANTIBODIES BIND, AND DETERMINING THE TISSUE AND CELLULAR DISTRIBUTION OF THE CARBOHYDRATES. THE FEASIBILITY OF GENERATING SUCH MONOCLONAL ANTIBODIES WILL BE EXAMINED IN PHASE I. HYBRIDOMA CELL LINES THAT SECRETE MONOCLONAL ANTIBODIES TO RHAMNOGALACTURONAN-I, A PLANT CELL-WALL DERIVED POLYSACCHARIDE, WILL BE GENERATED. THE COMPLETE STRUCTURE OF THE EPITOPE RECOGNIZED BY AT LEAST ONE OF THE ANTIBODIES WILL BE DETERMINED. THESE STUDIES WILL BE EXTENDED IN PHASE II TO INCLUDE CHARACTERIZATION OF EPITOPES RECOGNIZED BY OTHER ANTI-RHAMNOGALACTURONAN-I ANTIBODIES AND GENERATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO ADDITIONAL PLANT-DERIVED OLIGO- AND POLYSACCHARIDES.

* information listed above is at the time of submission.

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