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Activated protein C peptides for radio-mitigation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AI127065-01A1
Agency Tracking Number: R43AI127065
Amount: $591,344.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: R
Solicitation Number: PA15-065
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-04-14
Award End Date (Contract End Date): 2019-03-31
Small Business Information
Cincinnati, OH 45219-2399
United States
DUNS: 182472162
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (513) 652-8883
Business Contact
Phone: (513) 475-6618
Research Institution

The purpose of the proposed grant application is to further develop a therapeutic
regimen focused on radiological nuclear medical countermeasuresVery few medical
products have been shown to counter the acute and long term injuries that can result
from a nuclear or radiological accident or attackMedical products and regimens that
mitigate and or treat radiation injury post exposurei eadministration of first dose to
start at leasthours after radiation exposurewith emphasis on broad activityi emulti syndrome and or multi tissueease of administration in a mass casualty and
emergency scenariosafetyand long shelf life are still to be developed and are thus of
high priorityTherapeutic administration of recombinant proteins to lethally irradiated
wild type mice resulted in mitigation of lethal total body irradiationThese findings
suggest that pharmacologic augmentation of the activity such proteins might offer a
rational approach to the mitigation of tissue injury and lethality caused by ionizing

* Information listed above is at the time of submission. *

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