Non pharmacological improvement of sleep structure in older people

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43AG056250-01
Agency Tracking Number: R43AG056250
Amount: $348,951.00
Phase: Phase I
Program: SBIR
Awards Year: 2017
Solicitation Year: 2015
Solicitation Topic Code: NIA
Solicitation Number: PA15-052
Small Business Information
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DUNS: 079464958
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (732) 668-1250
Business Contact
Phone: (732) 668-1250
Research Institution
ABSTRACT Poor sleep and memory problems are common in older adults and have considerable consequences including decreased productivity declines in cognitive abilities increased rate of accidents and traffic fatalities and increased health care costs These sleep and memory problems often occur in midlife and in older adults when aging is associated with insomnia fragmentation of sleep and impairment of attention Aging also impacts sleep stages and sleep depth with marked changes in non rapid eye movement NREM sleep an increase in lighter NREM sleep stages N or N stage of sleep and a decrease in deep or slow wave sleep N stage of sleep Because deep sleep has been associated with the recuperative function of sleep memory consolidation and growth hormone release age related reduction in deep sleep has a negative impact on physiologic restoration memory and overall health The overall objective of this proposed research is to develop a non pharmacological means to address sleep deficiencies and well being in older midlife adults Several laboratory studies recently demonstrated that precisely delivered specific auditory stimulation in adults results in an enhancement of slow waves on the electroencephalogram EEG and improvement in memory Since older adults have a significant reduction in deep sleep increasing slow wave production by precisely delivered auditory stimulation could be particularly useful for this population To date the use of auditory stimulation to improve sleep has been limited to adult volunteers in laboratory settings Our objective is to validate modify and improve the application of specific auditory stimulation to increase deep sleep in older individuals and to develop a system that can deliver slow wave sleep enhancement in the home Both healthy people and patients with disturbances of sleep and memory could benefit from using this system It will be especially useful in older people Our new system will be inexpensive simple and easy to use PROJECT NARRATIVE We propose to develop an efficient and inexpensive system that could administer auditory stimulation during non rapid eye movement sleep and thus be widely used to improve quality of sleep and memory in humans Midlife and older people will particularly benefit from using this system

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