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Wireless System for Ambulatory Rodents to Measure Pressure and Volume in the Left Ventricle

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43HL132705-01A1
Agency Tracking Number: R43HL132705
Amount: $224,953.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NHLBI
Solicitation Number: PA15-269
Timeline
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-05-01
Award End Date (Contract End Date): 2019-04-30
Small Business Information
6901 EAST FISH LAKE ROAD, SUITE #188
Maple Grove, MN 55369-5457
United States
DUNS: 140696332
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 TIMOTHY RIEHLE
 (612) 730-1091
 triehle@koronisbiotech.com
Business Contact
 PATRICK LICHTER
Phone: (763) 515-5321
Email: plichter@koronisbiotech.com
Research Institution
N/A
Abstract

Abstract
In this Phase I SBIR Koronis Biomedical Technologies proposes to develop and evaluate a fully
implantable wireless device that monitors left ventricular pressure and volume P V in rodent studies
Transgenic models of heart disease have been created through hypothesis driven research on rodents that
seeks to both identify mechanistic pathways in academic research and support the development of novel
compounds and medications by large pharmaceutical companies As a result it has become increasingly
important to accurately and thoroughly evaluate cardiac function in the mouse and rat model Although
implanted telemetric pressure systems have been successfully commercialized for both mice and rats a
device that also measures real time volume in a free roaming rodent has been absent to date The
proposed miniature lightweight fully implanted device will collect pressure and volume measurements
using an admittance measurement technique and wirelessly transmit the measured data to a nearby base
station Narrative
Rodent models of heart disease are used by academic scientists and pharmaceutical companies to prove
drug safety and efficacy There is a need for a telemetric left ventricular pressure volume system to assess
rodent cardiac parameters

* Information listed above is at the time of submission. *

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