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STTR Phase I: Utilizing Natural Variation to Increase the Antioxidant Carotenoid Content in High Yielding Corn Varieties

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1721692
Agency Tracking Number: 1721692
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: BT
Solicitation Number: N/A
Timeline
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-07-01
Award End Date (Contract End Date): 2018-06-30
Small Business Information
1281 Win Hentschel Blvd, Unit 046, Lafayette, IN, 47901
DUNS: 080259004
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Evan Rocheford
 (765) 273-8274
 evan@nutramaize.com
Business Contact
 Evan Rocheford
Phone: (765) 273-8274
Email: evan@nutramaize.com
Research Institution
 Purdue University
 Torbert Rocheford
 Young Hall
155 South Grant Street
West Lafayette, IN, 47907-2114
 Nonprofit college or university
Abstract

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project will be the development and commercialization of a novel variety of corn that is high in carotenoids and orange in color, and with yields that are competitive with today's commercial hybrids. In the diets of Americans, two important antioxidant carotenoids, lutein and zeaxanthin, are in low abundance. This deficiency has been associated with higher risk for degenerative diseases such as Age Related Macular Degeneration, and potentially, dementia. The ultimate goal of the proposed research is to get American's to consume more lutein and zeaxanthin, which will be achieved by increasing significantly the levels of these antioxidants in the most widely grown staple crop: Corn. Since corn is used in a wide variety of popular processed food formats, improving the carotenoid content of corn provides an opportunity to significantly increase the amount of health benefiting antioxidants that Americans consume, without changing consumers eating habits. However, in order for this strategy to be economically feasible, corn varieties that are high in carotenoids must be developed that are also high in grain yield. This STTR Phase I project proposes to develop genetic markers for favorable alleles of genes associated with carotenoid biosynthesis and stability. There is considerable genetic variation in genes associated with carotenoid biosynthesis and stability, however, the most favorable alleles are typically not found in varieties that are commercially relevant to US corn production. Thus, the development of genetic markers will enable favorable alleles to be moved from lower yielding germplasm that is not well adapted to the US Corn Belt into elite inbreds suitable for the production of yield-competitive commercial F1 hybrids for the US market. The primary goal of this Phase I research is to create user-friendly genetic markers associated with favorable alleles for 12 key genes associated with carotenoid biosynthesis and stability. These markers will then be validated for efficacy by testing their ability to create progenies with higher carotenoid production, particularly lutein and zeaxanthin. This will result in a set of markers and experimental breeding materials that can be used to rapidly develop fixed inbreds for use in the production of yield-competitive high carotenoid F1 hybrids.

* Information listed above is at the time of submission. *

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