AUTOMATED SYNTHESIS OF NITROGEN-13-LABELED OCTYLAMINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7123
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1987
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
950 Gilman St, Berkeley, CA, 94710
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARIA STRAATMANN
 (615) 966-7539
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE DEVELOPMENT OF AN AUTOMATED SYNTHESIS MODULE (ASM) FOR THE PRODUCTION OF NITROGEN-13-LABELED OCTYLAMINE IS PROPOSED. NITROGEN-13-LA-BELED OCTYLAMINE IS A PROMISING LUNG-IMAGING AGENT. HOWEVER, BECAUSE OF THE SHORT HALF-LIFE OF NITROGEN-13 (10 MINUTES), THE SYNTHESIS MUST BEPERFORMED IN A RAPID, AUTOMATED MODULE FOR WIDESPREAD UTILIZATION IN THE HOSPITAL ENVIRONMENT. THE NEW ASM MODULE WILL EFFICIENTLY REMOVE THE NITROGEN ISOTOPE FROM THE TARGET OF THE SMALL MEDICAL CYCLOTRON AND PERFORM THE NECESSARY CHEMISTRY TO PRODUCE THE DESIRED NITROGEN-13-LABELED OCTYLAMINE WITHIN 30 MINUTES. THE COMMERCIAL AVAILABILITY OF SUCH AN EFFECTIVE LUNG-IMAGING AGENT, COMBINED WITH THE MANY OTHER INNOVATIONSPRESENTLY OCCURRING IN POSITRON EMISSION TOMOGRAPHY (PET), COULD GREATLY ENHANCE PET. COMPUTER TECHNOLOGY AND IMAGING, INC. IS DEVELOPING AND WILL BEGIN SUPPLYING PET CENTERS WITH SYSTEMS THAT WILL SELL FOR LESS THAN TYPICAL MAGNETIC RESONANCE IMAGING SCANNERS.

* Information listed above is at the time of submission. *

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