THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A DEVICE TO AID IN THE INVESTIGATION OF A NOVEL PROCEDURE FOR LONG-TERM CRYOPRESERVATION OF ORGANS.

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4874
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1986
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Conaway Inc
Po Box 785, 6611 Liggett Road, Dublin, OH, 43017
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 ROBERT M CONAWAY
 PRINCIPAL INVESTIGATOR
 (614) 766-0200
Business Contact
Phone: () -
Research Institution
N/A
Abstract
THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A DEVICE TO AID IN THE INVESTIGATION OF A NOVEL PROCEDURE FOR LONG-TERM CRYOPRESERVATION OF ORGANS. THE PRESERVATION PROCEDURE INVOLVES THE USE OF ULTRAHIGH HYDROSTATIC PRESSURE (I.E., ABOUT 6300 ATMOSPHERES) DURING THE FREEZING AND THAWING PROCESSES. INTEGRATION OF THIS APPROACH WITH MODIFIED EXISTING PROTOCOLS FOR CRYPPRESERVATION IS ANTICIPATED. THEAPPARATUS WILL APPLY HYDROSTATIC PRESSURES ON THE ORDER OF 6300 ATMOSPHERES IN INTERVALS AS SHORT AS 0.1 SECOND AS WELLAS INDEFINITELY LONGER PERIODS, AND MAINTAIN SUCH PRESSURES AS LONG AS DESIRED. TEMPERATURES WILL BE CONTROLLED INDEPENDENTLY AND WILL RANGE TO BELOW -150 C. THE CHAMBER WILL ACCOMODATE A SAMPLE OF ABOUT 2 CM DIAMETER AND 8 CM LENGTH. PERFORMANCE EVALUATIONS WILL BE CARRIED OUT TO FULLY CHARACTERIZE THE OPERATING RANGE AND TO ESTABLISH THE NECESSITY FOR ANY MODIFICATIONS OF A FINAL COMMERCIAL MODEL.SEVERAL TISSUE SAMPLES WILL BE PROCESSED USING RELATIVELY SIMPLE PROTOCOLS. THESE SAMPLES WILL BE EXAMINED FOR EVIDENCE OF THE EFFECTIVENESS OF THE ULTRAHIGH PRESSURE TECHNIQUE.

* information listed above is at the time of submission.

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