THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A DEVICE TO AID IN THE INVESTIGATION OF A NOVEL PROCEDURE FOR LONG-TERM CRYOPRESERVATION OF ORGANS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4874
Agency Tracking Number:
4874
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Po Box 785, 6611 Liggett Road, Dublin, OH, 43017
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
ROBERT M CONAWAY
PRINCIPAL INVESTIGATOR
(614) 766-0200
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PURPOSE OF THIS RESEARCH IS TO DEVELOP A DEVICE TO AID IN THE INVESTIGATION OF A NOVEL PROCEDURE FOR LONG-TERM CRYOPRESERVATION OF ORGANS. THE PRESERVATION PROCEDURE INVOLVES THE USE OF ULTRAHIGH HYDROSTATIC PRESSURE (I.E., ABOUT 6300 ATMOSPHERES) DURING THE FREEZING AND THAWING PROCESSES. INTEGRATION OF THIS APPROACH WITH MODIFIED EXISTING PROTOCOLS FOR CRYPPRESERVATION IS ANTICIPATED. THEAPPARATUS WILL APPLY HYDROSTATIC PRESSURES ON THE ORDER OF 6300 ATMOSPHERES IN INTERVALS AS SHORT AS 0.1 SECOND AS WELLAS INDEFINITELY LONGER PERIODS, AND MAINTAIN SUCH PRESSURES AS LONG AS DESIRED. TEMPERATURES WILL BE CONTROLLED INDEPENDENTLY AND WILL RANGE TO BELOW -150 C. THE CHAMBER WILL ACCOMODATE A SAMPLE OF ABOUT 2 CM DIAMETER AND 8 CM LENGTH. PERFORMANCE EVALUATIONS WILL BE CARRIED OUT TO FULLY CHARACTERIZE THE OPERATING RANGE AND TO ESTABLISH THE NECESSITY FOR ANY MODIFICATIONS OF A FINAL COMMERCIAL MODEL.SEVERAL TISSUE SAMPLES WILL BE PROCESSED USING RELATIVELY SIMPLE PROTOCOLS. THESE SAMPLES WILL BE EXAMINED FOR EVIDENCE OF THE EFFECTIVENESS OF THE ULTRAHIGH PRESSURE TECHNIQUE.

* information listed above is at the time of submission.

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