Keratin Biomaterials for Cranio-facial Tissue Engineering

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$99,260.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-10-C-0165
Award Id:
96854
Agency Tracking Number:
O093-H10-3014
Solicitation Year:
n/a
Solicitation Topic Code:
OSD 09-H10
Solicitation Number:
n/a
Small Business Information
1st Floor, Richard Dean Building, 391 Technology Way, Winston-Salem, NC, 27101
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
827054219
Principal Investigator:
LukeBurnett
Senior Scientist
(336) 202-1307
luke.burnett@keranetics.com
Business Contact:
KimWestmoreland
Co-Managing Director
(336) 918-6405
kim.westmoreland@keranetics.com
Research Institute:
n/a
Abstract
The majority of personnel injured in OIF/OEF have suffered blast effects from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair. There is a significant need to develop better platform technologies for these injuries and translate them into clinical and commercial use. A family of biomaterials derived from keratin proteins may provide a platform on which regenerative strategies can be built. Keratins have broad biocompatibility and can be formulated as films, foams, gels, fibers, or solid tissue constructs. One of the problems with many synthetic and naturally derived biomaterials is that they do not promote cell adhesion and migration into scaffolds that have weak cell-matrix interactions. Keratins have intrinsic cell-binding properties that can be exploited to offer potential new solutions to cranio-facial regeneration. This Phase I proposal seeks to perform initial testing of keratin materials using primary cell types relevant to cranio-facial tissues. Assessments will be made regarding cell attachment, proliferation, gene expression and other cell specific assays to validate that keratin materials provide a permissive extracellular matrix-like environment. Results will be used to tailor specific types of keratin proteins into biomaterial scaffolds for use in large animal cranio-facial defect studies to be conducted in Phase II.

* information listed above is at the time of submission.

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