You are here

A Novel Scaffold to Promote Skin Regeneration

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AR070681-01A1
Agency Tracking Number: R41AR070681
Amount: $225,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIAMS
Solicitation Number: PA16-303
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-14
Award End Date (Contract End Date): 2019-08-31
Small Business Information
Mount Pleasant, SC 29464-5641
United States
DUNS: 602545654
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (843) 388-3276
Business Contact
Phone: (843) 860-8785
Research Institution
2200 W MAIN ST, SUITE 820
DURHAM, NC 27705-4673
United States

 Nonprofit college or university

Dermal scarring affects more than million people worldwide annually over million people are
injured in motor vehicle accidents over million patients are severely burned and thousands of warriors are
wounded in military blasts In severe burns more than of patients develop hypertrophic scar contraction
which leads to hypertrophic scar contractures HSc HSc are stiff shrunken scars that limit mobility impact
quality of life and cost millions of dollars per year in surgical treatment and physical therapy HSc are caused
by increased mechanical tension and occur months after injury Current tissue engineered scaffolds such
as IntegraTM have mechanical properties akin to unwounded skin but the collagen based scaffolds rapidly
degrade over months being too short lived to prevent HSc The key to preventing HSc is having a
biocompatible scaffold which degrades over months To achieve this goal the development of scaffolds
composed of viscoelastic copolymer poly lactide co caprolactone PLCL is proposed Published work has
demonstrated that electrospun m thick PLCL scaffolds possess appropriate mechanical properties for
implantation beneath skin grafts and inhibition of HSc in mice However electrospinning cannot be used to
generate scaffolds at thickness necessary for large animal studies due to the great voltage gradient required
for scaffold production To overcome this hurdle solvent casting particulate leaching SCPL will be used to
create D porous PLCL scaffolds This method involves the mixing of polymers with particles within an organic
solvent followed by casting into a mold Water is then passed through the mold to leach out the particles
resulting in an interconnected porous D scaffold This SPCL method has successfully been used to create
mm thick PLCL scaffolds which have appropriate mechanical properties and tunable porosity for implantation
beneath skin grafts We hypothesize that optimized SCPL PLCL scaffolds will promote graft bioincorporation
and dampen fibrosis in vivo The three Aims to test our hypothesis are
Aim Determine SCPL manufacturing parameters to create uniform PLCL scaffolds with controlled pore size
porosity and mechanical properties
Aim Determine the optimal porosity of collagen coated SCPL PLCL scaffolds for tissue ingrowth
Aim Evaluate the safety and efficacy of optimal porosity PLCL scaffolds at promoting skin graft survival
The completion of these aims will validate a scalable method to create PLCL scaffolds and test them in
rodent and swine wound models for safety and efficacy The results will bring us closer toward developing an
optimized technology that prevents HSc with the potential to improve millions of lives worldwide PROJECT NARRATIVE
Scarring is a significant medical problem that affects more than million people worldwide annually and can
have many etiologies Currently available skin substitutes for wound healing have suboptimal degradation
rates leading to the formation of hypertrophic scars that limit mobility impact quality of life and cost millions of
dollars per year in surgical treatment and physical therapy This work will create and validate a unique
degradable scaffold with a prolonged degradation rate that promotes graft bioincorporation and prevents
hypertrophic scarring

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government