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A practical and versatile high resolution D dosimetry system for clinical use

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41CA217421-01A1
Agency Tracking Number: R41CA217421
Amount: $299,962.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 102
Solicitation Number: PA16-303
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-01
Award End Date (Contract End Date): 2018-08-31
Small Business Information
Skillman, NJ 08558-1632
United States
DUNS: 144967242
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (609) 306-0806
Business Contact
Phone: (609) 306-0806
Research Institution
2200 W MAIN ST, SUITE 820
DURHAM, NC 27705-4673
United States

 Nonprofit college or university

Quality assurance QA is a critical component of radiation oncology that ensures both effective
treatment delivery and patient safety Over the last decade dQA is now particularly important
asramatic innovations in treatment delivery technologiesy have led to increasingly sophisticated
and complex treatments that are difficult to adequately verify with conventional dosimetric
verification systems Corresponding innovations in verification technologies haves lagged
behind generating a potentially dangerous imbalance where traditional verification systems
lack sufficient capability to adequately verify these new treatmentsopportunity for new paradigm
changing comprehensive D dosimetry QA systems In this proposal we address this lack and
need by developing a novel truly D treatment verification measurement system based on a D
radiochromic dosimeter Presage with optical CT readout There are two specific aims i to
optimize two advanced prototype Presage formulations see below and ii to optimize a novel
low cost D optical scanner
The objective of the first aim is to optimize two advanced prototype Presage formulations for
application to remote and re useable D dosimetry respectively AIn remote dosimetry highly
stable prototype Presage formulation will be optimized that will enable remote dosimetry
consisting of dosimeters are shipmentped from a central base institution to a remote institution
for irradiation and then shipped back to the base institution for readout and analysis A post
irradiation stableThis formulation formulation will improve enable the comprehensiveness of
remote credentialing and or auditing tests The second sub aim is to optimize aA second re
useable formulation formulation will be optimized where the post irradiation optical
densitydosimeter gradually `clearsandapos within weeks and the dosimeter can then be re used
This formulation will allow economic in house use for centers with a readout optical CT
system Potential formulation modifications have been identified Initial studies in cuvettes will
identify successful formulations which will then be scaled up to relevant D dosimeter
dimensions for evaluation by the DUKE optical scanner
The second aim will beis the optimization of the DUKE optical CT scanner for commercial
application in a general clinic which will be conducted by the co PI Dr Oldham of DUKE Prior
scanners have worked defined state of the art performance well but require expensive
telecentric optical lenses and large volumes of refractive index matching fluids and substantial
expertise making the system impractical for the general clinic In this aim we leverage new D
printing techniques to solve both of these challenges through creation of a novel light
collimating solid tank The proposed research develops a scanning system willwhich
eliminates the need for both telecentric the lenses and minimize the amount ofalmost all of
refractive index matching liquid This will be achieved by manufacturing a solid tank which both
surrounds the dosimeter and collimates light into parallel ray geometry
The long term goal is to commercialize the the Presage Optical CT system and meet the need
for an economic but hugely capable fully D dosimetry system for the general clinic capable of
in house use with re useable PRESAGE formulations or for remote offsite long distance
credentialing type verification stable PRESAGE The Presage Optical CT D dosimetry
system will be a listed FDA medical device commercially sold by Heuris Inc Project Narrative
Radiation therapy is a principle treatment modality for many cancers In the last yearsdecade
the sophistication and complexity of treatment delivery has increased dramatically Corresponding
advances in treatment verification has lagged behind however creating a dangerous imbalance
because comprehensive end to end treatment verification is widely recognized as essential to
safe and effective treatment implementation This proposal will develop a novel state of the art
and highly cost effective D dosimetry system that can provide a uniquely powerful solution to the
problem of comprehensive end to end dosimetry verification

* Information listed above is at the time of submission. *

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