Turnkey THz Spectroscopy Polarimetry System for Pharmaceutical Applications

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41GM125486-01
Agency Tracking Number: R41GM125486
Amount: $216,808.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 400
Solicitation Number: PA16-303
Timeline
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-01
Award End Date (Contract End Date): 2019-07-31
Small Business Information
858 W PARK ST, Eugene, OR, 97401-2929
DUNS: 009296513
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 VLADIMIR KOZLOV
 (541) 653-6505
 vgkozlov@mtinstruments.com
Business Contact
 RENEE ISLEY
Phone: (541) 683-6505
Email: sales@mtinstruments.com
Research Institution
 CALSPAN-UNIVERSITY OF BUFFALO RES CENTER
 BOX 400, 4455 GENESEE ST
BUFFALO, NY, 14225-1955
 Domestic nonprofit research organization
Abstract
ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on proteins for potential drug targets By looking at differences in absorption of polarized light between different relative molecular orientations vibrational resonances can be isolated from the isotropic background which generally obscure these features This measurement system will enable a researcher to readily mount a protein microcrystal and immediately have the intramolecular vibrational fingerprint to readily see if and how this fingerprint has changed with single point mutations or binding This characterization of intramolecular dynamics will be done without the need to introduce an external tag to the system under study The main technological hurdle that will be addressed during this phase I project that will be crucial to the commercialization is the vast simplification of the data acquisition A high brightness terahertz source will be developed that will allow intensity based detection of the spectroscopic data This source will use a high power fiber laser and a quasi phase matched nonlinear crystal to generate tunable narrowband terahertz output The second technological improvement will be the development of polarization control module which will allow data acquisition without moving the sample which is necessary for fast data collection Finally an integrated sample holder detection module will be developed that allows users to easily change samples without disturbing the alignment into the detector Information on long range structural vibrations is of particular interest in design of allosteric drugs which bind to a location distant from the active site on a molecule The current interest in allosteric drugs is due to their distinct advantages over orthosteric drugs drugs that bind directly to the active site Currently there are research efforts dedicated to gaining a better fundamental understanding of the mechanisms behind allostery with the goal of eventually predicting how action at distant sites modulates protein activity This information will stream line drug discovery efforts reduce costs for the drug industry and cost of medications for the patients More importantly it will have a much broader societal impact by expediting the drug discovery process and making new drugs available faster NARRATIVE This project aims to produce an instrument that is capable of rapidly characterizing long range structural vibrations in proteins In the long term the information obtained from this instrument can be used in conjunction with computational models to identify binding sites on proteins for potential drugs

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government