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Point of Care Imaging for Cardiovascular Monitoring Light Energy Tissue Interactions

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41HL133633-01A1
Agency Tracking Number: R41HL133633
Amount: $224,869.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NHLBI
Solicitation Number: HL14-017
Solicitation Year: 2014
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-05
Award End Date (Contract End Date): 2019-05-31
Small Business Information
Greenville, NC 27834-9013
United States
DUNS: 079509088
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (919) 280-2953
Business Contact
Phone: (919) 280-2953
Research Institution
GREENVILLE, NC 27858-5235
United States

 Nonprofit college or university

A research team of clinical medicine optical physics mechanical and electrical engineering disciplines at
ECU has invented a new biomedical imaging technology Multi Spectral Physiologic Visualization MSPV
MSPV is a proprietary laser illuminated hardware software imaging system that is non contact cm
imaging distance non invasive no dyes or injections non ionizing no X ray CT and poses no risk to
patients MSPV is a platform technology multiple clinical applications to visualize image analysis and
quantify blood flow in vessels and perfusion in tissues in real time during surgical procedures and clinic
The ECU team and its commercialization partner RFPi LLC have also documented derivation of
Physiologic Status Parameters PSPs from the metadata of this physiologic based MSPV imaging
This Phase I proposal will study two aspects of MSPV directly related to Point Of Care POC applications
Imaging Optimization and Monitoring Accuracy In POC settings medical standards of quality and
accuracy must be met to reduce complications and prevent avoidable deaths The Hypothesis of this STTR
Phase I Research Strategy is that the MSPV specifications can be optimized for tissue specific blood
flow perfusion analyses and the medical accuracy of PSPs can be validated at the optimized specifications
For Imaging Optimization Specific Aim data are needed to better understand light energy tissue
interactions across the tissues that can be imaged in surgeries at POC heart GI organs skin veins arteries
muscle healing tissues to then optimize MPSV to tissue specific configurations For Monitoring Accuracy
SA preliminary validation of PSPs for medical quality and accuracy is needed to design a portable
hand held POC device for MSPV visualizations PSP determinations and trend analyses
Optical physics research techniques with phantoms will be used SA to examine depth of penetration
refraction reflection energy transfer and power density at different illumination wavelength configurations
In SA normal volunteers will undergo MSPV imaging of the palmar surface of the hand at optimal skin
MSPV configurations derived PSP data will be correlated with data from current POC monitoring devices
The findings from both Aims will be important new data SA results should provide the technical
specification pathway for RFPi to develop tissue specific applications for MSPV flow and perfusion
visualization and quantification SA results should catalyze development of RFPiandapos s vision for a
transforming POC monitoring technology solution Both results bring new physiologic data to POC to
drive better decision making based on real time and trended data improve clinical care quality and
reduce healthcare costs Medical technologies that give immediate new data to providers at point of care are evolving A new imaging
technology that provides real time blood flow and tissue perfusion data has been developed This project will
study two clinical application aspects of this technology Imaging Optimization and Monitoring Accuracy

* Information listed above is at the time of submission. *

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