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Quantitative Non Invasive Brain Imaging using Magnetic Nanoparticles

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DA043974-01
Agency Tracking Number: R41DA043974
Amount: $225,211.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIDA
Solicitation Number: DA17-010
Solicitation Year: 2017
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-01
Award End Date (Contract End Date): 2019-07-31
Small Business Information
Newton, MA 02459-3605
United States
DUNS: 079591740
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 (617) 755-3838
Business Contact
Phone: (617) 755-3838
Research Institution
BOSTON, MA 02114-2696
United States

 Domestic Nonprofit Research Organization

This Phase I STTR project is based upon a new technique Quantitative Ultra short Time to Echo
Contrast Enhanced QUTE CE MRI utilizing UTE sequences with SuperParamagnetic Iron Oxide Nanoparticles
SPION that leads to quantifiable vascular images with unprecedented clarity and definition QUTE CE is
particularly optimal using Ferumoxytol an FDA approved iron oxide nanopharmaceutical The technique was
developed by PI Sridhar and his team at Northeastern University Northeastern University has licensed the
QUTE CE MRI method to Theranano LLC for commercial translation The TheraNano QUTE CE MRI
product is an imaging suite comprised of methods and software for quantitative non invasive brain imaging
customized for use by clinical radiologists This Phase I STTR project will develop the QUTE CE MRI suite and
validate with first in human studies The specific aims of this project are summarized here
Specific Aim Develop and Optimize QUTE CE protocol for D clinical imaging at T This project
will primarily use the Siemens T TrioTim MRI scanner with channel head coil tasks will be pursued to
develop the optimizing protocol Task Develop a UTE imaging protocol Task Develop a robust trajectory
for improved image reconstruction and signal quantification Task Implement a robust methodology for
accounting for B inhomogeneity Specific Aim Validate the QUTE CE neuroimaging suite with studies
in healthy human subjects These studies will be carried out at Massachusetts General Hospital MGH under
the direction of Dr Mukesh Harisinghani a world renowned expert in clinical nanoparticle imaging and Dr John
Chen an expert neuro radiologist The studies will have full approval of the MGH IRB healthy volunteers will
be imaged in the Siemens Trio T scanner with Ferumoxytol contrast agent and using the protocol optimized in
Aim Blood draws will be taken before and after administration for validation of the quantitative estimation of
the blood CA Specific Aim Develop the QUTE CE MRI suite for non invasive quantitative brain imaging
A radiologist friendly software suite will be developed for presentation and analysis of the subject scans The
suite will present results for whole brain angiography full brain voxel based cerebral blood volume CBV
maps the first CBV map of the human brain by registering the voxular data on a human brain map The
analysis will also provide time dependent data for the blood pool concentration of contrast agent which will be
cross checked with elemental analysis of the blood draw assay
QUTE CE MRI addresses three critical unmet needs Positive contrast imaging with a safe contrast
agent providing an alternative to Gd based contrast agents that have been shown to be toxic Non invasive
live whole brain vascular imaging with exceptional clarity and definition Quantitative MRI where an absolute
measurement of CA concentration is assayed competitive with nuclear imaging but without radiation toxicity
The proposed studies should lead to groundbreaking results on brain function and neurological health PROJECT NARRATIVE
TITLE Quantitative Non Invasive Brain Imaging Using Magnetic Nanoparticles
This Phase I STTR project will develop a non invasive brain imaging technique QUTE CE MRI and validate the
method with first in human studies The project will establish a human vascular atlas and will enable
quantitative diagnosis of cerebrovascular abnormalities by revealing abnormal regions of the brain that
characterize disease a tool which doesnandapos t currently exist and which could lead to many exciting discoveries
and clinical applications in neurology

* Information listed above is at the time of submission. *

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