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Commercialization of a Novel Therapeutic for Alzheimer's Disease

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R42AG044187-02A1
Agency Tracking Number: R42AG044187
Amount: $1,059,937.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PA16-092
Timeline
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-30
Award End Date (Contract End Date): 2020-05-31
Small Business Information
404 CLYDEBANK CT, Louisville, KY, 40243-1805
DUNS: 841834083
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 MARK LOVELL
 (859) 257-1412
 malove2@pop.uky.edu
Business Contact
 MARK LOVELL
Phone: (859) 257-1412
Email: malove2@pop.uky.edu
Research Institution
 UNIVERSITY OF KENTUCKY
 500 S. LIMESTONE
LEXINGTON, KY, 40526-0001
 Nonprofit college or university
Abstract
ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production of Ain mouse models of AD pathology through Elkmediated transcriptional repression of presenilinbut not presenilinAlthough our preliminary data show BNCeffectively modulatesof the main pathologic features of AD without the adverse effects associated with current monotherapeuticsthere is a need for characterization of its basic pharmacology toxicity and for identification of the most efficacious treatment regimen in a well characterized mouse model of Adeposition and neuroinflammationX FAD miceIf successfulthe data obtained in this proposal will provide necessary pharmacology safety toxicology data to de risk the drug for potential corporate partners thus increasing the likelihood of successful commercialization

* Information listed above is at the time of submission. *

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