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FrostBite BC A New Thermal Ablation Device for Treating Bladder Cancer

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA210761-01A1
Agency Tracking Number: R43CA210761
Amount: $308,550.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 102
Solicitation Number: PA16-302
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-11
Award End Date (Contract End Date): 2019-01-31
Small Business Information
Owego, NY 13827-1515
United States
DUNS: 150225337
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (607) 687-8701
Business Contact
Phone: (607) 687-8701
Research Institution

The need for the development of new strategies for treatment of bladder cancer BC has experienced
a palpable increase in the last few years While several options are currently under investigation many
if not all remain suboptimal This is critical as it is estimated that in there were new
cases and over deaths from BC worldwide In the US alone there were new cases
and over deaths from BC This makes BC the th most prevalent and th deadliest cancer
worldwide While various treatment options currently exist a number of issues have been reported
including the high cost of treatment patient discomfort complications incomplete treatment procedural
invasiveness and poor efficacy among others With a yr survival rate for BC patients ranging from to
yielding a reported deaths in alone far above prostate or breast cancer there is
an ever growing urgency and compelling need for the development of new strategies and devices to
treat BC The intent of this project is to develop a new cystoscopic based thermo molecular treatment
strategy and catheter system FrostBite BC for the treatment of BC employing a minimally invasive
trans urethral outpatient procedure The prototype unit and preliminary data collected to date strongly
support the potential of this approach The major goals of this Phase proposal are the following
Develop the FrostBite BC catheter system and bench test it using non tissue engineering models
Test this new treatment protocol in a homogeneous and heterogeneous cell population BC tissue
engineered model TEM Test the ability of an adjunctive nutraceutical compound Vitamin D to
sensitize BC cells to freeze injury cryosensitization thereby making cryoablation more effective while
protecting normal cells and conduct a pilot in vivo study to validate development Phase will
include optimizing the catheter device and procedure conducting pre clinical in vivo studies and
determining the potential role of FrostBite BC launching a whole body immune response against
metastatic disease in vivo The successful completion of this project will lead to a new minimally
invasive cystoscopic compatible trans uretheral approach for the treatment of bladder and other
urogenital cancers Once completed this project will provide for an effective minimally invasive
treatment for patients afflicted with BC as well as other urologic based cancers resulting in improved
patient survival quality of life and mitigating risk factors for cancer diagnosis This application proposes to develop a novel thermo molecular therapeutic strategy for
the treatment of bladder cancer

* Information listed above is at the time of submission. *

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