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Electrochemical Paper-Based Analytical Devices for Metal Determination

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44ES024041-02
Agency Tracking Number: R44ES024041
Amount: $991,695.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: PA16-302
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-15
Award End Date (Contract End Date): 2019-08-31
Small Business Information
Fort Collins, CO 80524-2674
United States
DUNS: 078845198
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (414) 469-8508
Business Contact
Phone: (970) 491-2852
Research Institution

Project Summary
The goal of this project is to develop a new sampling and analysis system combining two new technologiesA
lightweight ultrasonic sampler will be paired with an electrochemical paper based analytical deviceePADfor
measurement of metals in airborne particulate matterPMExposure to particulate matterPMair pollution
ranks as theth leading risk factor for human morbidity and mortality worldwideoutpacing the health risks of
all other environmental hazards combinedAlthough PM is a complex mixture of many potentially toxic
compoundsthe transition and heavy metal content present in PM is thought to play a significant role in toxicityThe disease burden posed by PM is supported by strong epidemiologic links between population exposure and
many forms of ill healthe gcardiovascular diseaserespiratory diseaseneurological disordersand cancerDespite these scientific linkslittle is known about individuali epersonalair pollution exposures because
existing technologies for assessing personal PM exposure are expensiveburdensomeand complicatedFurthermorePM sample analysis techniquesespecially for transition and heavy metalsare prohibitively high$s sampleand require the use of a centralized laboratory and specialized staffAccess Sensor
Technologies has a vision to change this sampling and measurement paradigm by providing low costhighperformance tools for quantifying personal exposure to PM toxicantswith an emphasis on metalsThe global
market for air pollution monitoring exceeds $ Bwe seek to leverage this market with a disruptive technology
than can revolutionize the state of the art in personal exposure monitoringDuring Phase Ithe basic analytic
chemistry using electrochemical paper based analytic devicesePADsand sample processing componentry
for measuring metals were developed and demonstratedDuring Phase IIwe will develop a product line that
includes a wearablesilentlightweightcompactair samplera streamlined module for chemical analysisand
the software interface necessary for mobile phone operation and communicationsthistotal analysis systemwill streamline the process of exposure and risk assessment while dramatically lowering costWe will validate
this system through laboratory and field studies against gold standard methodsThe outcome of this project
will be products designed to penetrate research and consulting markets in industrial hygiene and
environmental monitoringwith a long term goal of offering a low cost consumer product For this Phase II
projectwe willIntegrate AST s proprietary air sampling technology with a streamlined analytic kit for in field
filter ex traction and metals analysisDevelop an inexpensive and disposable sensor for rapidsimultaneous
quantification of multiple met als from a single air sampling filter andDemonstrate product viability through
field testing with early stage commercial partnersIf successfulwe will also have product applications beyond
particulate air pollutionas the sensor paradigm is amenable for watersoiland food analyses as wellThere is
an urgent global need for simpler cheaper analysis of the world around us

* Information listed above is at the time of submission. *

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