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Oxidative Stress Biosensor for Breath Based Environmental Monitoring

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43ES026931-01A1
Agency Tracking Number: R43ES026931
Amount: $149,914.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIEHS
Solicitation Number: PA16-302
Solicitation Year: 2016
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-15
Award End Date (Contract End Date): 2018-03-31
Small Business Information
West Palm Beach, FL 33401-6223
United States
DUNS: 827877486
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (650) 938-6200
Business Contact
Phone: (650) 938-6200
Research Institution

This application seeks to develop a non invasive and practical optical sensor technology to monitor and
quantify oxidative health Oxidative stress OS is a biochemical imbalance in which production of reactive
oxygen species exceeds the system s antioxidant capacity Failure to repair or contain cumulative oxidative
damage is likely responsible for the pathogenesis of many acute and chronic illnesses including cardiovascular
and kidney disease inflammatory responses neurodegenerative disorders and carcinogenesis A noninvasive
inexpensive robust sensor capable of evaluating and monitoring systemic oxidative stress would be a tool of
great value to public health officials clinicians and individual consumers since many environmental
conditions and xenobiotics e g urban air pollution heavy metal contamination endocrine disrupting
compounds pesticides and industrial chemicals trigger oxidative stress Because there is no universal
biomarker for OS and there are many potential target molecules it s critical to develop a system that is capable
of detecting many chemical components and creating a chemical fingerprint that reflects alterations in key
pathways associated with environmental stressors iSense LLC has developed a novel sensor array that can
detect a vast library of volatile compounds across multiple chemical moieties at ppb level concentrations The
technology is rapid inexpensive and capable of distinguishing between single analytes and complex mixtures
Our breath sensor has been used to detect the biosignature of lung cancer patients and differentiate between
different types of lung cancer in humans Phase I of this project will test improve and optimize this breath
analysis technology towards the detection and identification of key biomarkers of oxidative stress Successful
completion of this work will establish the fundamental chemistry necessary to develop a device to measure and
understand markers of environmental exposure PROJECT NARRATIVE
The proposed research will develop and test a novel array based optical sensor for the detection and
identification of biomarkers of oxidative stress in exhaled breath If successful the proposed effort will yield
technology to generate a chemical fingerprint for measurement of oxidative stress resulting from environmental

* Information listed above is at the time of submission. *

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