You are here

An interactive patient specific virtual surgical planning system for upper airway obstruction treatments

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43EB023121-01
Agency Tracking Number: R43EB023121
Amount: $225,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NIBIB
Solicitation Number: PA15-269
Timeline
Solicitation Year: 2015
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-09-01
Award End Date (Contract End Date): 2019-08-31
Small Business Information
28 CORPORATE DR
Clifton Park, NY 12065-8688
United States
DUNS: 010926207
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ANDINET ENQUOBAHRIE
 (919) 969-6990
 andinet.enqu@kitware.com
Business Contact
 KATIE OSTERDAHL
Phone: (518) 836-2187
Email: proposals@kitware.com
Research Institution
N/A
Abstract

Abstract
Surgery is a common mode of treatment for conditions such as septal deviation turbinate hypertrophy
sleep apnea and tracheal stenosis resulting from upper airway obstruction Current diagnosis and the
subsequent decision making of these pathologies primarily rely on the clinical examination and objective
measures such as acoustic rhinometry and rhinomanometry that do not correlate well with patient symptoms
The lack of dependable objective measures has resulted in improper procedural prescriptions and less
accurate surgical corrections Therefore providing the surgeons with reliable patient specific objective
measures to a assist in choosing the appropriate surgical procedure b predict and quantify the outcome of a
particular or a combination of surgical procedures is essential In this project we propose to develop an
integrated surgical planning system for upper airway obstruction treatment We aim to maximize the surgical
success rate through informed decision making achieved using an interactive surgical planning system that
can provide quantitative physical metrics based on accurate air flow simulations
This project is a close collaboration between Kitware Inc Medical College of Wisconsin MCW and
University of North Carolina UNC The co investigators from MCW and UNC have developed computational
fluid dynamics CFD simulations in D models constructed from CT scans that emulate resting inspiratory
airflow in the nasal cavity They have showed that several biophysical metrics computed from CFD models
correlated well with subjective measures of symptoms before and after surgery In a separate project a team
at Kitware has spearheaded the development of Virtual Pediatric Airway Workbench VPAW a software
program that provides a complete pipeline to support surgical planning for treatment for commonly occurring
upper airway problems in young children starting with CT scans In this project we propose to combine the
expertise of teams from MCW UNC and Kitware to extend VPAW to develop a fully functional patient specific
geometrical and simulation based surgical planning system for upper airway obstruction treatment using nasal
airway obstruction NAO surgical treatment as a proof of concept The specific aims of the proposed project
are a Extend VPAW for surgical planning of other upper airway obstruction treatment and b Evaluate the
extended VPAW surgical planning system by comparing the CFD metrics resulting from virtual surgery with
post surgical flow simulation metrics in actual patients to assess potential equivalency of the models The
successful completion of this work will result in a proof of concept surgical planning system thus paving the
way for further developments and clinical studies during Phase II Project Narrative
Surgery is a common mode of treatment for conditions such as septal deviation turbinate hypertrophy
sleep apnea and tracheal stenosis resulting from upper airway obstruction Current surgical procedures lack
dependable objective measures resulting in improper procedural prescriptions and surgical corrections with low
long term success rate In this project we aim to maximize the surgical success rate through informed
decision making achieved using an interactive surgical planning system that can provide quantitative physical
metrics based on accurate air flow simulations

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government