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I-Corps training for SBIR Phase 1 Project Rapid Induction of Therapeutic Hypothermia Using Ice Slurry

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43HL139151-01
Agency Tracking Number: R43HL139151
Amount: $274,966.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NHLBI
Solicitation Number: PA18-517
Solicitation Year: 2017
Award Year: 2017
Award Start Date (Proposal Award Date): 2017-08-01
Award End Date (Contract End Date): 2018-08-31
Small Business Information
Westford, MA 01886-1137
United States
DUNS: 080735671
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (978) 727-2783
Business Contact
Phone: (978) 727-2783
Research Institution

Project Summary Abstract
SignificanceAbout one thousand patients suffer cardiac arrest in United States each dayonlyof them surviveTherapeutic hypothermiaTHhas been demonstrated to increase the survival rate and neurological outcome of the cardiac
arrest patientsDue to the limitation of existing cooling methodssuch as slow cooling speed and or late induction of
hypothermianone of these methods can meet the key requirementsi ethe timing and speed with which the hypothermia
to be inducedto gain the optimal benefits of hypothermiaIt results in less thanof eligible patients actually benefiting
from hypothermia treatmentBuy Time MedicalBTMinvented a novel cooling device to infuse ice slurrya specially
processed micro particulate iceinto the blood vessel of cardiac arrest patient for rapid organ or body coolingPilot large
animal experiment demonstrated thatL ice slurry infusion can potentially cool the entire body of an adult human at a rate
ofC hrwhich is several folds faster than any other existing cooling methodsBTM s ice slurry cooling device provides
a new capability to induce hypothermia by paramedics to meet the timing and speed requirements for optimal outcomeSpecific aimsIn this I Corps training programour three member team will participate in on site Course Kick off and
Course Close out sessionsand weekly online Courses to build business model canvasWe will conductinterviews to
end users and stakeholders that may influence our device on marketAfter each interviewwe will gradually develop value
proposition of our deviceunderstand user case and pain point to position our deviceidentify key activitiesresourcesand
partnersand channelsand define cost structureThe results will be incorporated in Commercialization Plan of our phase
II proposal and direct its research focusUltimatelythe knowledge will help us to orient our regulatoryreimbursedistributionand market strategies and generate significant socio economic value Project Narrative
Mild therapeutic hypothermia has been demonstrated to improve the patient survival rate and neurological
outcome of cardiac arrestwhich a leading cause of death in the United StatesOur project is to develop
and test a new cooling device that will be able to induce hypothermia earlier and quicker after onset of
cardiac arrest and verify its feasibility in animal study using a swine modelI Corps training will
significantly help us define commercialization plan that eventually will save lives of cardiac arrest
patients and generate socio economic value

* Information listed above is at the time of submission. *

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