LASER-ACTIVATED COLLAGEN ADHESIVES FOR HERNIORRHAPHY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$98,874.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43DK062571-01
Award Id:
60867
Agency Tracking Number:
DK062571
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
CONVERSION ENERGY ENTERPRISES, 81 PINE BROOK RD, SPRING VALLEY, NY, 10977
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
BARBARA SOLTZ
(845) 425-9170
BARBARA@CONVERSIONENERGY.COM
Business Contact:
BARBARA SOLTZ
(914) 425-9170
BARBARA@CONVERSIONENERGY.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): Approximately 1 million inguinal herniorrhaphies are performed annually in the US. Laparoscopic approaches have been developed but clinical acceptance has been hampered by problems such as stability of the mesh fixation, inadequate peritoneal closure, adhesion formation and the probability of internal herniae development. Laser assisted tissue welding using a derivatized collagen solder for tissue/mesh attachment may avoid compression or tissue injury which frequently occurs with mechanical fixation and may offer the additional benefit of minimizing postoperative pain due to tissue ischemia and nerve entrapment syndromes. This study will investigate laser-activated collagen solders for mesh attachment and closure. Laser operating parameters will be optimized to promote strong solder crosslinks to gastrointestinal tissue. An integrated temperature feedback controller will be used to prevent peripheral tissue damage. The proposed study includes the accurate measurement of previously unknown values for inherent solder strength, repair strength and type of failure mode. A surgical handpiece will be modified for use in animal experiments. By comparing a conventional method for mesh fixation to laser attachment, weld integrity, tissue healing and inflammatory response will be defined.

* information listed above is at the time of submission.

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