LASER ASSISTED CARTILAGE REPAIR USING COLLAGEN ADHESIVES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AR048738-01
Agency Tracking Number: AR048738
Amount: $98,402.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
CONVERSION ENERGY ENTERPRISES
CONVERSION ENERGY ENTERPRISES, 81 PINE BROOK RD, SPRING VALLEY, NY, 10977
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 BARBARA SOLTZ
 (845) 425-9170
 BARBARA@CONVERSIONENERGY.COM
Business Contact
 BARBARA SOLTZ
Phone: (914) 425-9170
Email: BARBARA@CONVERSIONENERGY.COM
Research Institution
N/A
Abstract
Articular cartilage damage affects millions of people. This condition is exacerbated by an ageing but increasingly more active population. The two portentous independent variables associated with inferior treatment of articular cartilage lesions are healing response and cartilage regeneration. Laser-assisted welding using a derivatized collagen solder may aid in the prevention of progressive degenerative joint disease and may augment or ultimately replace total joint arthroplasty. We have assembled a multi-disciplinary team to investigate the efficacy of laser activated collagen formulations as an adhesive and as an acellular graft that permits and/or promotes cell invasion. Laser operating parameters will be optimized to promote strong solder crosslinks to cartilage. An integrated temperature controller will be used to prevent peripheral tissue damage. A laser handpiece will be modified for use in the animal studies. Custom designed equipment will be used to accurately measure previously unknown values for inherent solder strength, strength of the repair and type of failure mode. Histology will assess the potential to promote cell invasion and synthesis of new extracellular matrix. It is anticipated that the Phase I results will lay the foundation for further animal studies and clinical trials in subsequent Phase II and Phase III projects

* information listed above is at the time of submission.

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government