Development of a Novel Bioreactor System for Engineered Tissues

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0201
Agency Tracking Number: O093-H11-3090
Amount: $99,998.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2009
Solicitation Topic Code: OSD09-H11
Solicitation Number: 2009.3
Small Business Information
3455 University Parkway, Winston-Salem, NC, 27106
DUNS: 807911511
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Kerr Spencer
 Chief Executive Officer
 (781) 771-1357
Business Contact
 Matthew Bloom
Title: Business Development Manager
Phone: (315) 521-7651
Research Institution
The devastating traumatic injuries sustained by warfighters in OIF/OEF frequently involve the loss of large portions of bone, muscle and skin. Current management of tissue coverage and augmentation involves the use of existing host tissue to construct, for example, muscular flaps or grafts. In many instances this approach is not feasible due to lack of viable tissue and/or donor site morbidity. Such complications delay or prohibit rehabilitation and restoration of tissue function. Tissue engineering of bulk functional tissue may provide a solution for these injuries. Recent studies have documented the importance of bioreactor preconditioning in vitro to the enhanced function of engineered skeletal muscle following implantation in vivo. We will leverage these initial findings to address the critical need for clinical translation and commercial use of platform bioreactor technologies required to treat these injuries. An established protocol for engineered skeletal muscle will provide a model system to create novel bioreactors capable of both noninvasive real-time imaging of engineered tissue formation and promotion of vasculogenesis. The result will be a “next generation” bioreactor system capable of noninvasive high throughput evaluation of various cell sources and biomaterials, as well as production of tissues that can overcome existing size limitations for functional reconstruction.

* Information listed above is at the time of submission. *

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